Leprosy (Hansen’s disease) is a chronic infectious disease caused byMycobacterium lepraethat primarily affects the skin, peripheral nerves, eyes, and mucous membranes. It has been known for well over 2000 years and afflicts more than 11 million people worldwide, mostly in underdeveloped nations. ...
The disease course in leprosy is interspersed with lepra reactions, which are hypersensitivity reactions and are the main cause of morbidity in leprosy. Leprosy is also considered one of the leading causes of infectious peripheral neuropathy. It is associated with both sensory and motor impairment ...
Leprosy is a curable disease if detected in early stages, and early detection is critical for the prevention of disabilities [1]. In the United States, approximately 75% of new cases were detected in immigrants in 2010 [3]. Most leprosy patients in the USA were affected by lepromatous ...
Florida, USA, has witnessed an increased incidence of leprosy cases lacking traditional risk factors. Those trends, in addition to decreasing diagnoses in foreign -born persons, contribute to rising evidence that leprosy has become endemic in the southeastern United States. Travel to Florida should ...
However, the WHO TPP published in 2023 [31] was leading in terms of required minimum Sn/Sp for establishing a cut-off. An indecisive range was determined by calculating a lower-specificity cut-off (average of a set of negative controls + 2 × SD) and a high-specificity cut-...
the strains circulating in the Southern USA and associated with zoonosis from the nine-banded armadillo, I-30, NHDP-55 and NHDP-6318, originated much more recently (Fig.3b), in agreement with the rapid expansion and spread of the armadillo population since its introduction to this region about...
Bassel Ghaddar Martin J. Blaser Subhajyoti De Nature Computational Science (2023) Spatial transcriptomics in human biomedical research and clinical application Weining Hu Yin Zhang Xiaodong Fang Current Medicine (2023)Sections Figures References Abstract Data availability Code availability References Acknow...
Data acquisition was performed by FACsCanto flow cytometer (BD-USA) and analyzed in the BD FCAP Array software, where values were expressed in pg/mL for both analytes. 2.4. Data analysis Statistical analyses were carried out using the GraphPad Prism 6.0 software package (San Diego, CA, USA)...
in: Conn’s Current Therapy (Rakel & Bope, ed.), pp. 101–106, Elsevier Science (USA), St. Louis, MO (2003). Google Scholar Rea, T. H., and Jerskey, R. S. Clinical and histologic variations among thirty patients with Lucio’s phenomenon and pure and primitive diffuse lepromat...
that study of the interactions between pathogens and the immune system is reciprocally providing extraordinarily valuable insights in the fundamental questions of function and regulation of the immune system. Leprosy provides a wonderful example of the reciprocity between basic immunology and clinical ...