GMP Lentiviral Vectors Production Lentivirus Integration Site Analysis Service Custom CRISPR Lentiviral Library Replication-Competent Lentivirus Testing Custom CAR Lentiviral Service Lentivirus Testing Services Lentiviruses (LVs) are an attractive gene delivery vehicle for a wide broad of applications. LVs offer...
Reference reagent for lentivirus vector integration site analysis Cat No. CBPL0002 Format Genomic DNA Description The product can be used for the safety assessment of the genetic editing cell therapy method (including CART therapy). This product is dual -verified by the NGS (capture method) ...
This integration step, catalyzed by the viral-encoded integrase, ensures long-term expression of the viral genes, thus allowing a productive viral replication and rendering retroviral vectors also attractive for the field of gene therapy. At the same time, this ability to integrate into the host ...
Inverse PCR strategy for integration site analysis demonstrated integration of at least 1 or 2 copies of GFP in the transgenics, mapping to different chromosomes. GFP expression was detected in a wide range of murine tissues, including testis and the transgene was stably transmitted to a third ...
Therefore, LV integration pattern in genomic DNA obtained from day 7 SmartDC-TRP2 was analyzed by linear amplification mediated-PCR (LAM-PCR) and next-generation sequencing and the clonal frequencies were monitored with a high-throughput integration site (IS) analysis.31 The number of total ...
An integration-defective lentivirus-based resource for site-specific targeting of an edited safe-harbour locus in the human genome. C. An integration-defective lentivirus-based resource for site-specific targeting of an edited safe-harbour locus in the human genome. Gene Ther. 21, ... Torres,...
Inverse PCR strategy for integration site analysis demonstrated integration of at least 1 or 2 copies of GFP in the transgenics, mapping to different chromosomes. GFP expression was detected in a wide range of murine tissues, including testis and the transgene was stably transmitted to a third ...
Therefore, LV integration pattern in genomic DNA obtained from day 7 SmartDC-TRP2 was analyzed by linear amplification mediated-PCR (LAM-PCR) and next-generation sequencing and the clonal frequencies were monitored with a high-throughput integration site (IS) analysis.31 The number of total ...
Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells. Gene Ther 2013; 20: 201–214. Article CAS Google Scholar Wanisch K, Yáñez-Muñoz RJ . Integration-deficient lentiviral vectors: a slow coming of age. ...
Safety data, including adverse events (AEs), vector integration site analysis, and surveillance for replication competent lentivirus (RCL), were evaluated post-infusion. The primary analysis period for the study is 24 months following in... J. Kwiatkowski,A. Thompson,J Rasko,... - 《Blood》...