Lentiviral vectors in gene therapy: their current status and future potential. Arch Immunol Ther Exp (Warsz) 2010; 58: 107-119 S- Editor Sun H L- Editor Kerr C E- Editor Ma WHEscors D,Brecktpot K.Lentiviral vectors in gene therapy:their current status and future potential[J].Arch ...
Corning offers gene therapy solutions for scaling up LV adherent cultures from 2D, single-use vessels to large-scale, and production-ready quantities.
Recombinant lentiviral vectors (rLV) are powerful tools for gene transfer to the central nervous system (CNS) and hold great potential as a therapeutic gene therapy strategy for neurological disorders. Recent data indicate that rLVs are suitable for functional studies in the CNS by over expression...
The invention relates to the use of viral vectors able to stably integrate into the genome of thymic stromal cells, or of intrathymic lymphocytes or lymphocytes precursors, for the manufacture of a medicine intended for intrathymic administration in the frame of the prevention or treatment of ...
Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and...
It also publishes Progress & Prospects reviews and News and Commentary articles, which highlight the cutting edge of the field.doi:10.1038/sj.gt.3302450A W NienhuisGene TherapyNienhuis AW.Lentiviral vectors for the treatment of Wiskott-Aldrich syndrome. Gene Therapy . 2005...
Get reliable, stable gene expression from SBI’s highly-regarded lentivectors—our wide range of promoters and reporters support a wealth of applications Browse All Lentiviral Expression Plasmids & Lentiviral Vectors Browse All Lentiviral Vectors Products LENTIVIRAL VECTORS pCDH-CMV-MCS-EF1α-GreenPuro...
gene therapyrhesus monkeysAdenosine deaminase (ADA)-deficient mice and healthy rhesus monkeys were studied to determine the impact of age at treatment, vector dosage, dosing schedule, repeat administration, biodistribution, and immunogenicity after systemic delivery of lentiviral vectors (LVs). In mice,...
Lentiviral vectors are promising tools for the genetic modification of cells in biomedical research and gene therapy. Their use in recent clinical trials for the treatment of adrenoleukodystrophy, -thalassemia, Wiskott-Aldrich- Syndrome and metachromatic leukodystrophy underlined their efficacy for therapies ...
Viral vectors for in vivo gene transfer in Parkinson’s disease: Properties and clinical grade production. Exp Neurol. 2008;209:58–71. Article CAS PubMed Google Scholar Choudhury SR, Hudry E, Maguire CA, Sena-Esteves M, Breakefield XO, Grandi P. Viral vectors for therapy of neurologic ...