Lentiviral vectorsSingle-use cell culture technologiesCost of goods modellingAutologous gene-modified cell therapiesCAR T-cellTCRHaematopoietic stem cell gene therapyPlasmid DNATraditional viral vector processes rely on lab-scale methods that need to be industrialised so as to avoid viral vector supply ...
Corning offers gene therapy solutions for scaling up LV adherent cultures from 2D, single-use vessels to large-scale, and production-ready quantities.
Although not without safety concerns, the properties of lentiviral vectors makes them an attractive choice for human gene therapy.doi:10.1517/13543784.7.6.997DropulicBoroExpert Opinion on Investigational DrugsDropulic, B. (1998) Novel lentiviral vectors for human gene therapy. Expert Opin. Investig. ...
gene therapyrhesus monkeysAdenosine deaminase (ADA)-deficient mice and healthy rhesus monkeys were studied to determine the impact of age at treatment, vector dosage, dosing schedule, repeat administration, biodistribution, and immunogenicity after systemic delivery of lentiviral vectors (LVs). In mice,...
Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and...
H. Wolfe. Lentiviral vectors for gene transfer to the central nervous system: applications in lysosomal storage disease animal models. In C. Machida (ed.), Viral vectors for gene therapy: methods and protocols , Humana Press, Totowa, NJ, 2002, pp. 383–403....
Viral vectors for in vivo gene transfer in Parkinson’s disease: Properties and clinical grade production. Exp Neurol. 2008;209:58–71. Article CAS PubMed Google Scholar Choudhury SR, Hudry E, Maguire CA, Sena-Esteves M, Breakefield XO, Grandi P. Viral vectors for therapy of neurologic ...
The invention relates to the use of viral vectors able to stably integrate into the genome of thymic stromal cells, or of intrathymic lymphocytes or lymphocytes precursors, for the manufacture of a medicine intended for intrathymic administration in the frame of the prevention or treatment of ...
In human gene therapy applications, lentiviral vectors may have advantages over γ-retroviral vectors in several areas, including the ability to transduce nondividing cells, resistance to gene silencing and a potentially safer integration site profile. However, unlike γ-retroviral vectors it has been ...
Get reliable, stable gene expression from SBI’s highly-regarded lentivectors—our wide range of promoters and reporters support a wealth of applications Browse All Lentiviral Expression Plasmids & Lentiviral Vectors Browse All Lentiviral Vectors Products LENTIVIRAL VECTORS pCDH-CMV-MCS-EF1α-GreenPuro...