Kochan, G., Escors, D., Stephenson, H., & Breckpot, K. Clinical Grade Lentiviral Vectors. Lentiviral Vectors and Gene Therapy., 69-85 (2012).D. Escors and K. Breckpot, "Lentiviral vectors in gene therapy: their current status and future potential," Archivum Immunolo- giae et erapi...
Lentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells. With the extensive and in-depth studies on this gene therapy vehicle over the past two decades, LVs have been wide...
Lentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells. With the extensive and in-depth studies on this gene therapy vehicle over the past two decades, LVs have been wide...
Lentiviral vectors and gene therapy Gene therapy is a novel method under investigation for the treatment of genetic, metabolic and neurologic diseases, cancer and AIDS. The primary goal of ge... K Ekaterina - 《Frontiers in Bioscience》 被引量: 0发表: 1999年 Lentiviral Vectors: Regulated Gene ...
In summary, this review shows how lentiviral vectors offer an interesting alternative for gene therapy in all ocular compartments. Keywords: lentivirus; viral vector; gene therapy; ocular delivery; retinal disease; glaucoma; cornea1. Basics of Lentiviral Vector Technology...
Activated glial cells in the dorsal spinal cord participate in the development and maintenance of pain after peripheral nerve injury. Our understanding of mechanisms involved in functional changes of spinal glia remains incomplete. Excepting drugs that c
Lentiviral vectors emerged as a powerful vaccine and gene therapy platform15,16,17,18,19,20, exhibiting several advantages over other viral vectors. Lentiviral vectors are majorly pseudo-typed with heterologous vesicular stomatitis virus envelop glycoprotein (VSV-G), to which human populations have ne...
Gene therapy with hematopoietic stem and progenitor cells is a promising approach to engineering immunity to human immunodeficiency virus (HIV) that may lead to a functional cure for acquired immunodeficiency syndrome (AIDS). In support of this approach, we created lentiviral vectors with an engineered...
Recombinant lentiviral vectors (rLV) are powerful tools for gene transfer to the central nervous system (CNS) and hold great potential as a therapeutic gene therapy strategy for neurological disorders. Recent data indicate that rLVs are suitable for functional studies in the CNS by over expression...
GD is a candidate for gene therapy as bone marrow transplantation has been shown to be curative which serves as a proof-of-concept that correction of haematopoietic stem cells (HSCs) can alleviate disease. This project produced lentiviral vectors carrying a range of constructs. GC was modified ...