Allen DG & Kentish JC (1985) The cellular basis of the length-tension relation in cardiac muscle. J Mol Cell Cardiol 17, 821-840.Gulati J. Molecular biology of the length-tension relation in cardiac muscle. Adv. Exp. Med. Biol. 332:593-60; discussion 601-2, 1993....
There is no single, unique active tension curve in the length-tension relationship in cardiac muscle. The slope and magnitude of the active tension curve at a particular preload depend upon the inotropic state of the muscle. If, for example, inotropy is increased by applying norepinephrine, the...
active tension increased with sarcomere length up to 3.6 m except when pCa was 5.0 in which case the tension measurements at greater sarcomere lengths than 3.0 m were not possible without compromising the sarcomere uniformity and A-band registration. It was concluded that sarcomeres (both cardiac ...
The distinguishing mechanical characteristics of cardiac muscle are(1) the presence of a significant and sometimes labile resting tension at functional lengths. Certain invertebrate skeletal muscles also possess this property, but the structural basis seems to be different.(2)Force-velocity characteristics...
. In skeletal muscle deviation from the ‘ideal’ curve shown in Fig. 1 has been attributed to variation in the degree of activation when the muscle is stimulated at different lengths. We have investigated this possibility in cardiac muscle by studying the effect on the length–tension relation...
We studied the effects of the damaged ends on the length-tension relationship of the cat right ventricular papillary muscle during twitch contraction (30/min) using a newly developed segment-control system. The segment length (SL), defined as the distance between two thin black films attached to...
The length-tension curve is a visual representation of the amount of tension generated by different muscle lengths. In general, muscle tension is greatest when muscles are at an intermediate length, that is neither too short nor too long. Why is the length-tension relationship important? The len...
BACKGROUND: At the basis of the Frank-Starling mechanism is the intrinsic ability of cardiac muscle to produce active tension in response to stretch. Titin, a giant filamentous molecule involved in passive tension development, is intimately associated with the thick filament in the sarcomere. Titin...
However, when length-tension curves were normalized with respect to maximal developed tension and length, a length-dependent activation was indicated by the separation of the curves. 3. These results suggest that length-dependent activation altered the inotropic state of cardiac muscle when length ...
The slope of the sarcomere length-tension relation in cardiac papillary muscle suggests length-dependent activation of the contractile system (1). However, there are no data on the effect of inotropic interventions on this curve. Only mu... HET Keurs,WH Rijnsburger,RV Heuningen,... - 《Circ...