Here, we studied the differential expression of the most important small G‐proteins during Leishmania infection. We found major changes in the expression of different isoforms of Ras, mainly in N‐Ras. We observed that Leishmania donovani infection led to enhanced N‐Ras expression, whereas it ...
Leishmaniais a genus of intracellular parasites that infect, survive and proliferate in antigen presenting myeloid cells, particularly dendritic cells, monocytes and macrophages1,2.Leishmania donovani(L. donovani) andLeishmania infantum(L.infantum) species cause visceral leishmaniasis (VL), which is u...
Leishmania donovaniinfection induced preferential recruitment of inflammatory monocytes. (A) Flow cytometric analysis of CD11b+ gated cells from the spleen and liver ofL. donovaniinfected mice at 24 hr post infection. (B) Kinetics of inflammatory monocyte recruitment was evaluated by flow cytometry at...
C57BL/6 mice were immunized against Leishmania donovani infection with a subcutaneous vaccination protocol. Groups received 3 injections at 4-day intervals combining glucan and killed promastigotes harvested from either logarithmic or stationary phase cultures. Controls were immunized with glucan alone, sta...
In both the 8-day and long-term models of Leishmania donovani infection in hamsters, it markedly diminished the parasitic load and proved to be less toxic than pentamidine. It rapidly improved the hematological picture of infected animals. Like pentamidine, it inhibited in vitro multiplication of ...
M. Kaye, "Dendritic cells, but no macrophages, produce IL-12 immediately following Leishmania donovani infection," European Journal of Immunol- ogy, vol... PMA Gorak,CRE And,PM Kaye - 《European Journal of Immunology》 被引量: 361发表: 1998年 B Cell-Deficient Mice Are Highly Resistant to...
Leishmania donovani infection in golden hamsters was studied as a model for human kala-azar. After intradermal inoculation of L. donovani amastigotes, hams... C Gifawesen,JP Farrell - 《Infection & Immunity》 被引量: 121发表: 1989年 Experimental murine Leishmania donovani infection: immunoprotec...
We have also previously reported that B cell-derived IL-10 production following Leishmania donovani infection was dependent on MyD88 expression in B cells (Bankoti et al., 2012). The protozoan parasite L. donovani is a causative agent of visceral leishmaniasis (VL), a chronic disease that ...
donovani infection induce alteration of human and murine host miRNA profiles25,26,27,28,29. Here, we investigate the role of L. (L.) amazonensis in the regulation of murine host miRNAs. Given the importance of parasite arginase in the establishment of infection through L-arginine metabolism, ...
donovani infection. (a–d) RAW264.7 cells (2 × 106) were treated with either AKTi (10 μM) for 1 h or transiently transfected with WT- or DN-AKT expression plasmids for 24 h. Both these macrophages were then infected with L. donovani promastigotes (macrophage:parasite ratio, 1:10) ...