——专为筛选实验提供超过56,000种具有阳性特征(Hit-like)和先导特征(Lead-like)的高度多样性杂环化合物。 Maybridge Hitfi… xingfulu521.blog.163.com|基于6个网页 2. 先导性的 ...库将具有重要的价值,它将帮助他们发现和合成新的具有先导性的(lead-like) 化合物。” ...
Post-HTS analyses need to prioritize compounds that are progressed to chemical probe or lead status. We report trends in probe, lead and drug discovery by examining the following categories of compounds: 385 leads and the 541 drugs that emerged from them; "active" (152) and "inactive" (1488...
(2007) Lead-like, drug-like or ``Pub-like'': How different are they? J Comput Aided Mol Des;21:113-119.Oprea TI, Allu TK, Fara DC, Rad RF, Ostopovici L, Bologa CG (2007) Lead-like, drug-like or "Pub-like": how different are they? J Comput Aided Mol Des 21:113-119...
Lead-like compounds have lower initial values for structural properties, allowing increases without becoming non-drug-like. The "hits" that serve as starting places for leads come from high-throughput screening, virtual screening, natural ligands, natural products, and the scientific literature. In th...
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1 首先：go down like a lead balloon 它的中文释义是完全的失败，也可以是不受欢迎，比如说同学们说了一个笑话给你的朋友。如果 你的笑话go down like a lead balloon 意思是他们一点都不喜欢，或你要上台唱歌，演讲，如果go down like a lead balloon 就是你的表演不受欢迎。当然你们都是希望表演和笑话...
《【预订】Lead Like a Black Belt: Transform Your Leadership Style》,作者:【预订】Lead Like a Black Belt: Transform Your Leadership StyleAlexander 著,出版社:,ISBN:9780615988948。