(4), where LDL-C = total cholesterol – (HDL-C + TG/5) (using values in mg/dl). However, there are several limitations with the Friedewald equation. Most importantly, the equation assumes a fixed TG:cholesterol ratio for estimating the concentration of VLDL-C (represented by TG/5 in ...
with the exception of the comparison of the 2 cholesterol markers, the I 2 statistic ranged in the low or near the low to moderate range of 25% to
[23] shows that eliminating PCSK9 from Apoe−/− mice decreases plasma cholesterol and VLDL and LDL cholesterol levels. Significantly, these mice accumulated less cholesterol ester in the atherosclerotic plaques, and the plaque sizes were decreased, although this did not reach significant levels. ...