These LDL-C goals were based on recommendations from 2018 ACC/AHA Cholesterol Clinical Practice Guidelines [4] or 2019 ESC/EAS Lipid Guidelines [3]. Calculations for each LDL-C goal threshold were applied on all patients in the study. No specific risk stratification was applied to select the ...
14-year period, age-adjusted high blood total cholesterol (≥240 mg/dL) in the US declined from 18.3% in 1999-2000 to 11.0% in 2013-2014, coinciding with the 2001 National Cholesterol Education Program Adult Treatment Panel (ATP)-III guidelines that endorsed LDL-Cholesterol (LDL-C) goals....
Importantly, and not unlike the ACC/AHA guidelines, statin therapy is the go-to treatment for elevated cholesterol, with the ESC/EAS recommending the highest dose tolerable to achieve treatment goals (class I, level of evidence A). For patients who are statin intolerant, ezetimibe (Zet...
Studies conducted in both the U.S. and Europe have shown that as many as 80% of high-risk, statin-treated patients are not currently meeting the new LDL cholesterol goals, including those who are also taking a second, non-statin cholesterol-lowering drug, Klug said. "It's for these pati...
Anacetrapib allowed significantly more FH patients to attain their LDL-cholesterol treatment goals, but researchers are urging caution with the agent because two others in the class have failed in large clinical-outcomes trials.
Although statin monotherapy could reduce LDL-C levels to a large extent (up to À50% with the highest doses of most potent statins), this might not be enough to reach the desired goals based on the individual CV risk, and therefore additional approaches are needed. This is even more ...
We also speculate that data from IMPROVE-IT are the first in what is expected to be a number of publications which will challenge the premise of the 2013 ACC/AHA lipid guidelines, namely, that achieved specific LDL-C goals are not as essential as what dose of statin the patient takes. We...
The 2013 ACC/AHA guidelines focus on statin intensity instead of LDL-C goals and suggest intensive treatment of elevated LDL-C among ASCVD patients. Duration of exposure to elevated LDL-C has been shown to increase risk of CV events demonstrating an urgency to lower uncontrolled LDL-C. The go...
LDL Cholesterol Goals in High-Risk Patients: How Low Do We Go and How Do We Get There? Besseling J, van Capelleveen J, Kastelein JJ, Hovingh GK (2013) LDL cholesterol goals in high-risk patients: how low do we go and how do we get... J Besseling,JV Capelleveen,JJP Kastelein,.....
Program Overview: Effectively managing high cholesterol level and safely lowering LDL-C is crucial for preventing and reducing the risk of adverse cardiovascular events. However, achieving LDL-C goals remains suboptimal, particularly in high-risk and very high-risk patients. The landscape of ...