Variation in the concentration of cholesterol in blood plasma is partly accounted for by differences in diet, age, sex and genetic constitution. No correlation between plasma low density lipoprotein (LDL) cholesterol concentration and the activity of the LDL receptor in white blood cells could be fo...
The high circulating LDL-cholesterol levels seen in the inherited disease familial hypercholesterolaemia cause high rates of cardiovascular disease whereas the low circulating LDL-cholesterol levels following statin treatment cause low rates of cardiovascular disease. This is why LDL-cholesterol is referred...
The high circulating LDL-cholesterol levels seen in the inherited disease familial hypercholesterolaemia cause high rates of cardiovascular disease whereas the low circulating LDL-cholesterol levels following statin treatment cause low rates of cardiovascular disease. This is why LDL-cholesterol is referred...
Caulfield6,8,z Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL ...
While these medications may be necessary for those with extremely high cholesterol, they can have unpleasant and even dangerous side effects. If you’re able to, balance your cholesterol levels naturally through lifestyle changes. Are you at risk?
The triglyceride and non-high-density lipoprotein cholesterol (HDL-C) levels explained 65% of the variance in the TG:VLDL-C ratio. Based on strata of triglyceride and non-HDL-C values, a 180-cell table of median TG:VLDL-C values was derived and applied in the validation data set to ...
This is a situation that could not be explained simply by comparing cholesterol levels in the two countries. Experts felt that this difference was due primarily to the French diet, which contains more red wine, fruits, and vegetables. Although red wine contains antioxidants and ...
In the cross-sectional study, levels of total cholesterol (TC) and LDL cholesterol (LDL-C) decreased and levels of HDL cholesterol (HDLC) increased with age in men (all P < .001) but not in women. In the prospective study, TC, LDL-C, and HDL-C levels all decreased in both men ...
cholesterol, while elevated plasma LDL levels are considered ‘bad’. Indeed, the increased consumption of fatty foods as part of a Western-style diet in the last 50 years [26] has led to intense focus on HDL as a protective factor against CVD [16] by reducing peripheral cholesterol levels...
It means that one person (person A) may have large cholesterol rich LDL particles, while another (person B) may have smaller cholesterol-depleted particles. These two persons may have the same LDL-C concentration. However, person B will have a LDLP. Despite similar levels of LDL-C, person...