The high circulating LDL-cholesterol levels seen in the inherited disease familial hypercholesterolaemia cause high rates of cardiovascular disease whereas the low circulating LDL-cholesterol levels following statin treatment cause low rates of cardiovascular disease. This is why LDL-cholesterol is referred...
Figure 1. Lipoprotein X Explained (1) Binding of bile to the FXR inhibits bile production and stimulates excretion. Reduced bile production leads to the inability to excrete cholesterol. (2) Cholesterol and phospholipids migrate to the blood, where together with other particles they bind to albumin...
Currently the total level is less valued than the individual levels of HDL and LDL. See these examples: Patient 1 - LDL 150, HDL 20 and VLDL 20 = total cholesterol of 190 Patient 2 - LDL 100, HDL 65 and VLDL 25 = total cholesterol of 190 From what has been explained so far...
Genetic variants at this locus explained around 1% of the variation in LDL-cholesterol concentrations, and were associated with about 15% of an SD change in LDL-cholesterol concentrations per allele, on the basis of a SD of around 1 mmol/L. With caveats, these variants might therefore have ...
cholesterol levels in three Korean populations Kyung-Won Hong1, Jieun Lyu1, So Hyun Lee1, Bo Youl Choi2, Sung Soo Kim1 and Yeonjung Kim1 Serum levels of lipids, such as cholesterol and triglycerides, are heritable risk factors for cardiovascular disease and targets for therapeutic intervention...
The discordance of the low-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio with alterative lipid parameters may explain the inconsistent association of CIMT with the LDL-C/HDL-C ratio. Therefore, this study aimed to explore the associations between LDL-C...
Lower LDL cholesterol levels were not a predictor of intracranial hemorrhage events in a new analysis of the TST trial.
The findings may be explained by the high level of smaller and cholesterol-depleted LDL particles at low HDL-C level, despite the low LDL-C level [26]. Low HDL-C is not enough to prevent elevated CIMT, but high level of smaller and cholesterol-depleted LDL parti- cles could increase ...
Inclisiran (The Medicines Company) sustainably reduces low-density-lipoprotein (LDL) cholesterol levels across genotypes in heterozygous familial hypercholesterolemia (HeFH) and in the primary prevention setting in high-risk patients, suggest the latest data from the ORION program. The research was ...
causes duodenal ulcers, and viral infections likeherpesandcytomegalovirusand elevated lipids. (6) For example,H. pylorileads to elevated levels of total cholesterol, LDL cholesterol, lipoprotein (a), ApoB or LDL particle number, and triglyceride concentrations as well as decreased levels of HDL. (...