Predictors of LDL-cholesterol goal achievement in secondary prevention in Europe and Canada: Results of the Dyslipidemia International StudyGitt, A KJuenger, CSmolka, WBestehorn, KLundman, PLeiter, LPedersen, TGonzalezJuanatey, JChazelle, F...
PCSK9 enhances LDL cholesterol (LDL-c) levels by escorting the liver LDL receptor (LDLR) to endosomes and lysosomes for degradation. PCSK9 monoclonal antibodies and RNA-antisense formulations are effective in reducing LDL cholesterol in patients. The recent structural identification of a novel pocket...
PCSK9 enhances LDL cholesterol (LDL-c) levels by escorting the liver LDL receptor (LDLR) to endosomes and lysosomes for degradation. PCSK9 monoclonal antibodies and RNA-antisense formulations are effective in reducing LDL cholesterol in patients. The recent structural identification of a novel pocket...
Cholesterol levels are in the unit of mg/dL (milligrams per deciliter of blood) in the USA. But, they can be in mmol/L (millimoles per liter) unit used in Europe, Canada, and other countries. Along with these pointers, it typically shows that total cholesterol above 240, and ...
Dias CS, Shaywitz AJ, Wasserman SM, Smith BP, Gao B, Stolman DS, et al. Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on stat...
Noun1.oxidized LDL cholesterol- LDL cholesterol that has been bombarded by free radicals; it is thought to cause atherosclerosis LDL cholesterol- the cholesterol in low-density lipoproteins; the `bad' cholesterol; a high level in the blood is thought to be related to various pathogenic conditions...
High LDL cholesterol is a strong marker of heart disease risk in the general population, but its use in people with chronic kidney disease (CKD) is unclear. To investigate, Marcello Tonelli, MD, FRCPC (University of Alberta, in Edmonton, Canada) and his colleagues studied 836,060 adults with...
Effects of a monoclonal antibody to PCSK 9 on low density lipoprotein cholesterol levels in statin intolerant patients: the GAUSS randomized trial J Am Med Ass, 308 (2012), pp. 2497-2506 Google Scholar 30 M.J. Koren, P. Lundqvist, M. Blognese, et al. Anti PCSK 9 monotherapy for hyperc...
The mean weight loss of the participants in this study was 10.2% of body weight. “Data from this controlled feeding study suggests that consumption of the Mediterranean diet, even in the absence of weight loss, decreases LDL cholesterol concentrat...
We found that oxidized low-density lipoprotein (ox-LDL) cholesterol significantly up-regulates both the expression of miRNA-223 and L-type calcium channel protein. In contrast, knockdown of miRNA-223 reduced L-type calcium channel protein expression, while genetic knockdown of endogenous miRNA-223 ...