Current ESC dyslipidemia guidelines recommend lowering LDL targets to 1.4mmol/L (55mg/dL) for very high risk individuals. Lipid levels of newborns may provide insights into physiologic levels at the time of birth. There is limited data on cord blood lipids/lipoprotein levels in Asian populations....
Polygenic risk scores could also be integrated with functional evaluations, including LDL uptake and lipid mobilization in peripheral blood cells, to construct hybrid scores useful for identifying subjects more prone to hypercholesterolemia [52]. Also, integration of polygenic scores with biochemical data,...