HDL-cholesterolLDL-cholesterolFrom 108 healthy 13 years old school children who took part on a longitudinal study in regard to serum lipids and lipoproteins 64 with normal body weight were examined. Lipoproteins
Oxidative damage of high-density lipoprotein (oxHDL) leads to a dysfunctional molecule, potentially a mediator and/or marker of cardiometabolic disease. We tested the hypothesis that circulating concentration of oxHDL is higher in obese (Ob) or T2DM adolescents compared to normal-weight (NW) peers...
What are the normal cholesterol levels for men and women? A cholesterol test generally determines 4 distinct numbers: Total cholesterol, LDL, HDL, and triglycerides. Cholesterol being fat, it is not soluble in water. So it cannot circulate freely in the blood. But, the fact is that nature ...
LDL in the blood has to enter the endothelium and cross it to reach the subendothelial area, where it is retained and accumulates over time. Electron microscopy studies have demonstrated that physiological levels of LDL particles can be internalized by two pathways; an LDL receptor (LDLR) depende...
MD2 levels are elevated in atherosclerotic lesion macrophages, and MD2 deficiency or pharmacological inhibition in mice reduces the inflammation and stunts the development of atherosclerotic lesions in Apoe−/− mice fed with high-fat diet. Transfer of marrow-derived cells from Apoe-Md2 double knock...
METHODS The samples of fasting blood-serum were collected from 25 patients with ischemic heart disease (IHD) and 23 normal controls with no cardiovascular disease, diabetes mellitus, and nephrosis. The levels of triglycerides (TG), cholesterol (Chol), high-density lipoprotein cholesterol (HDL-C),...
Atherosclerosis (AT) is a chronic inflammatory disease characterized by the accumulation of inflammatory cells, lipoproteins and fibrous tissue in the walls of arteries. AT is the primary cause of heart attacks and stroke and is the leading cause of deat
Levels of HDL-C were modestly increased by 5% to 10% across both the every-2-weeks and the monthly dose groups (4%-10% vs placebo at the mean of weeks 10 and 12) (eTables 3 and 6 and eFigure 2 in Supplement). Baseline PSCK9 levels were higher in the high-intensity statin ...
(95% CI) in each trial by the difference between treatment and control group marker levels in SDs from that trial. For comparability, the standard deviations reported by Boekholdt 4 (32 mg/dL for LDL‐C, 36 mg/dL for non‐HDL‐C, and 27 mg/dL for apoB) were used in each ...
At 6 and 12 weeks, the secondary outcomes evaluated were the percentage of patients reaching a total cholesterol/high density lipoprotein-cholesterol (TC/HDL-C) ratio 4 and mean percent change in TC, LDL-C, HDL-C, TC/HDL-C ratio, non-HDL-C, triglycerides (TG), and apolipoprotein- B (...