乳酸可阻止T细胞和NK细胞中NFAT的活化,使IFNγ产生减少,这与乳酸在炎性环境中促进IFNγ产生的作用相反。 LDHA的表达受HIF1α、MYC和p53调节,可促进上皮-间质转化,血管生成和侵袭增加。LDHB表达下调或缺失是前列腺癌、乳腺癌和胰腺癌等癌症发展中一个重要的早期事...
BMC Chemistry (2023) 17:70 https://doi.org/10.1186/s13065-023-00991-6 BMC Chemistry RESEARCH Open Access A study of the interaction space of two lactate dehydrogenase isoforms (LDHA and LDHB) and some of their inhibitors using proteochemometrics modeling Sedigheh Damavandi1, ...
While the contrasting findings may be explained in part by cell type–specific differences in the function of LDHA and LDHB, or by methodological differences, both papers question a nonredundant role of LDHA in aerobic glycolysis and delineate the limitations of therapeutically targeting the Warburg ...
lactate dehydrogenase: LDHA, LDHB and LDHCThis article has no abstract. Keywords: lactate dehydrogenase: LDHA, LDHB and LDHCJohana Vázquez‐MatíasLawrence Livermore National Laboratory Livermore CaliforniaHarvey W MohrenweiserLawrence Livermore National Laboratory Livermore California...
Conclusion: The FGF pathway facilitates glycolysis by activating LDHA and suppressing LDHB in a STAT1-dependent manner in PCa.doi:10.1186/s12967-024-05193-9Ye, YongkangYang, FukanGu, ZhanhaoLi, WenxuanYuan, YinjiaoLiu, ShaoqianZhou, Le
The mRNA of both LDHA and LDHB were expressed and no significant difference was observed in prepubertal testes. The mRNA levels of LDHB significantly increased during testicular development. In the adult testis,LDHA mRNA was not expressed. Expression studies revealed the presence of different LDH ...
ERRα modulates expression and activity of LDH. LDHA and LDHB expression levels were measured by quantitative real-time PCR.Delphine, MirebeauPrunierSoazig, Le PennecCaroline, JacquesJeanFred, FontaineNaïg, GueguenNathalie, BoutetBouzamondoAudrey, Donnart...
Mdluli K, Booth MP, Brady RL, Rumsby G (2005) A preliminary account of the properties of recombinant human glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism. Biochim Biophys Acta 1753:209-216. https://doi.org/ 10.1016/j.bbapap.2005.08...
Further data on chromosomal assignments of pig enzyme loci LDHA, LDHB, MPI, PEPB and PGM1, using somatic cell hybrids.doi:10.1111/j.1365-2052.1986.tb00725.xH. RyttmanP. TheboI. GustavssonB. GahneR. K. JunejaBlackwell Publishing Ltd...
In addition, functional predictions indicated that one SNP in LDHA, g.26304153G>A, may affect transcription factor binding and two SNPs, g.88544541A>G and g.88556310T>C could alter LDHB mRNA secondary structure. In summary, this study profiled the significant genetic effects of IDH2, LDHA,...