在clump_data()函数中,它的clump_r2和clump_kb参数分别与extract_instruments()函数里的r2和kb一致,它有一个pop参数需要注意一下,这个参数是用来指定参考基因组的人种的,默认值为pop=’EUR’,也即认为暴露的GWAS是欧洲人群,如果咱们研究的是中国人,则可以设置pop=’EAS’。 最后,我们不难发现剩下的IV和使用如下...
By identifying correlated SNPs from different platforms (r(2)=1), using PLINK's 'clumping' method, we generated combined p-values (using Fisher's combined and random effects meta-analysis) for each clump. P-values were corrected for the number of clumps (representing the number of independent...