We hypothesize that Tim-3 enhances CD8+ T cell function in acute infections and contributes to enhanced CD8+ effector function. Methods To test this hypothesis, we have used LCMV-specific TCR transgenic (P14) m
Here, we characterize in vivo TCR signaling in virus-specific CD8 T cells in the setting of chronic LCMV infection. We use virus-specific TCR transgenic CD8 T cells expressing theNr4a1-GFP reporter as proxy for TCR signaling in adoptive transfer experiments. Despite abundant availability of antige...
We hypothesize that Tim-3 enhances CD8+ T cell function in acute infections and contributes to enhanced CD8+ effector function. Methods To test this hypothesis, we have used LCMV-specific TCR transgenic (P14) mice expressing a truncated version of Tim-3 and CD8+ conditional deletion of Tim-3...