LCK与CD4和CD8相关,是控制T细胞增殖和活化的抗原的级联反应的一部分。它在胸腺发育中T细胞的选择和成熟以及成熟T细胞的活性中起关键作用。 LCK-Cre小鼠使用Lck基因的近端启动子,Cre酶在胸腺细胞发育的早期有较高表达,而在T细胞完全成熟后,Cre表达水平下降了大约10倍。
Pten flox/flox Lck-Cre mice developed thymic lymphomas, but before the onset of tumors, they showed normal thymic cellularity. To reveal a regulatory ... TJ Hagenbeek,M Naspetti,F Malergue,... - 《Journal of Experimental Medicine》
Faculty Opinions recommendation of Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development. D Wiest,A Contreras 被引量: 0发表: 2020年 THE ROLE OF ADAPTATION TO CLIMATE CHANGE IN RURAL DEVELOPMENT One of the most important consequences of...