The coating along the flow path is vapor deposited and prevents or severely decreases metal interactions between the metallic chromatographic system and the sample.Kerri M. SmithPaul Rainville
On all instruments, the default MS and ESI parameters were used. In the case of the ion trap instrument, only the optimized Target Mass (TM) parameter was used29. The absolute ionization efficiency values vary significantly depending on the ionization source geometry, ion optics, day, ...
Review and edit the compound adduct deconvolution used to quantify and identify a compound Recommended Use: For rapidly, objectively, and reliably discovering compounds of interest in LC-MS data analysis. Unlock complex data with powerful visualization One of the key features of...
EPA Method 1694: Agilent's 6410A LC/MS/MS Solution for Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biosolids by HPLC/MS/MS Application Note Environmental Authors Imma Ferrer and E. Michael Thurman Center for Environmental Mass Spectrometry University of Colorado Civil,...
Adduct calculator Fragmentation spectra matching Peak editor El-MAVEN installers are available for Windows (7 and above) and Mac OS (10.12 and above). Users can download the latest release for these platforms from theofficial website. Build from source ...
Then, 50 μL of the supernatant were 1:2 (v/v) diluted with 5 mM ammonium formate in water (pH 5.5–7.5) prior to LC–MS/MS analysis. LC–QTOF Analysis. Chromatographic separation was performed by using a Mediterranea Sea C18 analyt- ical column (50 × 4.6 mm...
The list of PPCPs that were analyzed in EPA Method 1694 along with the additional 18 analytes and internal standards are shown in Table 1A to 1E along with the optimized MRM transitions used for this study. 3 Table 1A. MRM Transitions and MS Operating Parameters Selected for the Analysis ...
Initial MS/MS experiments HDX analysis of a specific protein in conjunction with a specific protease, was initiated with the development of a preliminary accurate-mass reference "MS/MS-confirmed peaklist" (refMPL). Experimental details will be described in more detail elsewhere (Koter et al, in...
In silicofragmentation algorithm for predicted LPPs is based on the summarized knowledge of LPP MS/MS patterns. The algorithms include two major parts – the generation ofin silicofragmentation spectra and the fingerprintm/zlist.In silicofragmentation routes were formulated based on the data collected...
It was characterized by electrospray ionization LC–MS as a 2:1 hydrochlorothiazide–formaldehyde adduct of the parent drug substance. The adduct is believed to form through the double condensation reaction of hydrochlorothiazide with excess formaldehyde during the parent compound's synthesis. The ...