Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) Method for the Determination of Six Nitrosamine Impurities in ARB Drugs Principle The six nitrosamine impurities (NDMA, NDEA, NEIPA, NDIPA, NDBA, and NMBA) are separated from each other and from losartan by reverse phase chromatograph...
Liquid chromatography-high resolution mass spectrometry (LC-HRMS) is a popular approach for metabolomics data acquisition and requires many data processing software tools. The FAIR Principles – Findability, Accessibility, Interoperability, and Reusability – were proposed to promote open science and reusab...
LC-ESI-HRMS在化合物结构研究中的应用
The working principle and processing parameters are explained in detail. A ready-to-use script is provided in the supporting information.#The developed algorithm enables a comprehensible automated peak picking of non-target LC-MS data. Application to three completely different HRMS raw data files ...
HRMS techniques can overcome all the limiting factors of SIM/MRM analyte detection, thus representing an appropriate alternative to the use of QqQ instruments for targeted as well as nontargeted compound detection. Generally, HRMS measurements have enhanced performance in terms of confirmatory capabilities...
mined two years of LC-HRMS screening data with known MDMA exposure and identified known MDMA metabolites, thereby providing a proof-of-principle of the developed untargeted metabolomic strategy. The authors also observed changes in the endogenous production of serotonin and tryptophan, likely induced ...
Ultra-performance liquid chromatography coupled with high-reso- lution mass spectrometry (UPLC-HRMS) is considered as one of the most powerful tools to analyze metabolites because of the fast sepa- ration, high sensitivity, and excellent resolution17–19. Here, we present our work establishing a ...
(UPLC-HRMS) is considered as one of the most powerful tools to analyze metabolites because of the fast separation, high sensitivity and excellent resolution17,18,19. Here, we present our work establishing a searchable chemical fingerprint database of marine bacteria using UPLC-HRMS, together with...
Additionally, proof-of-principle data were obtained by the analysis of DBS samples obtained from healthy volunteers in non-fasting state as well as a sample from a diabetic volunteer treated with the fast acting analogue insulin Aspart. 展开 ...
Jin et al. [19] developed a nonlinear Prep-LC behavior and investigated the principle for purifying palmitoleic acid using octadecyl bonded stationary phases, which could be applied to establish purification methods for other unsaturated fatty acids. High-resolution mass spectrometry (HRMS) and nuclear...