LBX2-AS1Colorectal cancerM6A5-FUceRNARecent reports suggest that the long non-coding RNA LBX2 antisense RNA 1 (LBX2-AS1) acts as an important regulator in cancer progression, but its significance in colorectal cancer (CRC) remains undetermined. LBX2-AS1 expression levels in CRC were determined...
meRIP-PCR assays investigated the molecular mechanisms underlying the function of m6A in LBX2-AS1. Loss of function experiments was used to define the role of LBX2-AS1 in the progression of CRC. The ceRNA function of LBX2-AS1 was evaluated by RNA immunoprecipitation. In vitro and PDX models...
目的探讨长链非编码RNA(lncRNA)LBX2-AS1通过表皮生长因子受体(EGFR)信号通路调控胶质瘤细胞增殖、迁移及凋亡的机制。 方法2018年4月至2021年8月,将脑胶质瘤U251细胞(简称U251细胞)分为对照组和观察组,每组4株,对照组采用常规培养,观察组利用靶向LBX2-AS1的特异性小干扰RNA(siRNA)转染。采用四甲基偶氮唑盐法检测...
et al. Retraction Note: LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance. Cancer Cell Int 23, 32 (2023). https://doi.org/10.1186/s12935-023-02881-2 Download citation Accepted20 February 2023 Published23 February 2023 DOIhttps://doi.org/10.1186/s12935-023-...
摘要 目的基于生物信息学角度探讨长链非编码RNA(LncRNA)LBX2反义RNA1(LBX2-AS1)对结肠癌预后的影响并进行初步验证。方法在基因表达交互分析(GEPIA)数据库查找并明确与结肠癌预后密切相关的基因LBX2-...展开更多 Objective To explore the effect of long noncoding RNA(LncRNA)LBX2 antisense RNA 1(LBX2-AS1)...
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LBX2-AS1 possessed a potent expression in GC cells. RT-qPCR analysis of LBX2-AS1 in GC cell lines and normal gastric cell. Measurement of the efficacy of LBX2-AS1 knockdown via RT-qPCR in MGC803 and BGC823 cells. , Evaluation of proliferation ability of MGC803 and BGC823 cells ...
Mechanistically, lncRNA LBX2-AS1 could elevate the expression of BRD4, an oncogene, by competitively binding to miR-597-3p. More importantly, knockdown of lncRNA LBX2-AS1 increased the sensitivity of OS cells to the BRD4 inhibitor JQ-1. Finally, the tumor growth of...
表明LBX2-AS1是一种致癌性的lnc RNA,在胶质瘤中表达水平上调,并与患者预后相关,但其在胶质瘤中的作用机制尚不清楚.本研究首先检测了LBX2-AS1在胶质瘤细胞,组织中的表达情况,在此基础上进一步探讨了其致瘤作用及潜在机制.方法:1.通过分析TCGA,CGGA及GEO(GSE151352)中胶质瘤样本的RNA-seq数据,筛选出LBX2-AS1在...
LBX2-AS1gliomaproliferationmigrationLong non-coding RNAs (IncRNAs) have been proposed to play pivotal roles in the tumorigenesis of various malignant tumors.Previous studies have found that IncRNA LBX2-AS1 is involved in the progression of various tumors.However,currently,the expression and exact ...