Visual deprivation during a developmental sensitive period markedly alters visual cortical response properties, but the changes in intracortical circuitry that underlie these effects are poorly understood. Here
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 ...
We described eight morphological cell types in L4 of primary visual cortex (V1) in adult mice as well as the connectivity between the three most abundant cell types. We found that nearly all excitatory neurons in V1 L4 are pyramidal cells (as was previously described in rats27, guinea pigs...
Summary Parallel visual pathways from the retina to the primary visual cortex (V1) via the lateral geniculate nucleus are common to many mammalian species, including mice, carnivores, and primates. However, it remains unclear which visual features present in both retina and V1 may be inherited ...
Here we show that, in the main input layer of rat primary visual cortex, layer 4 (L4), recurrent excitatory synapses are endowed with multiple, devel-opmentally regulated mechanisms for induction and expression of excitatory synaptic plasticity. Maturation of L4 synapses and visual experience lead ...
visual pathwaySimple cells in layer 4 of the primary visual cortex are the first neurons in the visual pathway showing orientation and direction selective responses. The precise role of intracortical excitatory and inhibitory connections in generating these properties is still unclear. Intracortical ...
Only when interneurons with complex receptive fields were included, similar to those found recently in cat primary visual cortex (Hirsch et al, 2003), did the network behave appropriately. A critical feature in the model was that complex interneurons projected to simple interneurons but the simple ...
Our earlier studies on mice showed that classical conditioning in which monocular visual stimulation was paired with an electric shock to the tail enhanced GABA immunoreactivity within layer 4 of the monocular part of the primary visual cortex (V1), contralaterally to the stimulated eye. In the ...
Layer 4 (L4) is the initial site of sensory afference in barrel cortex and primary visual cortex (V1) in which excitatory inputs from thalamus, L6, and neighboring L4 cells are integrated. However, little is known about plasticity within L4. We studied plasticity at excitatory synaptic ...
In primate primary visual cortex, the sublaminated layer 4 was associated with a specialized core thalamocortical projection pattern. In primate primary motor cortex, no cytoarchitecturally distinct layer 4 was evident and the core thalamocortical projections terminated throughout layer 3. In the African...