By using immunocytochemistry for GS, we recently demonstrated a layer-specific, perisynaptic distribution of GS-immunoreactive astrocytes and their processes in perfusion-fixed rat hippocampi. Highest levels of immunoreactivity were found in well defined termination zones of glutamatergic hippocampal afferents...
Non-pial neocortical astrocytes have historically been thought to comprise largely a nondiverse population of protoplasmic astrocytes. Here we show that astrocytes of the mouse somatosensory cortex manifest layer-specific morphological and molecular differences. Two- and three-dimensional observations revealed...
Thus, layer-specific nAChR expression allows functional layer-specific control of cortical processing and plasticity by the BF cholinergic system, which is evolutionarily conserved from mice to humans. 1 Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU ...
Next, we wanted to determine if layer-specific complement activation resulted in layer-specific induction ofApoehighmicroglia in the mPFC. We performed RNAscope in situ hybridization (ISH) to quantitateApoeexpression in mPFC microglia, probing for Cx3cr1 mRNA as a microglia marker, andApoemRNA as...
It is likely that a more extensive analysis of RGCs by subtype using traditional anatomical parameters (i.e., soma size, dendritic stratification, Sholl analysis, dendritic field diameter) will reveal subtype-specific patterns in HCN channel expression and Ih properties. Indeed, single-cell transcrip...
The specific formation process of hollow fiber can be depicted in a ternary phase diagram. In the “dry-jet” step, the outer solvent evaporates so that the dope follows to the vitrified region and then the skin layer forms. In the “wet-quench” step, the water induces the phase ...
OPL (redirected fromOuter plexiform layer) Medical Wikipedia Category filter: AcronymDefinition OPLOttawa Public Library(Ottawa, Ontario, Canada) OPLOpen Content License OPLOpen Programming Language OPLOperator Plmn List OPLouter plexiform layer OPLOpen Publication License ...
Milosevic A, Noctor SC, Martinez-Cerdeno V, Kriegstein AR, Goldman JE. Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation. Mol Cell Neurosci. 2008;39:324–34. ...
Layer-specific modulation of tLTP in human cortex by nAChRs To test whether the laminar expression of nAChRs in human neocortex translates into layer-specific nicotinic modulation of synaptic plasticity, similar to mouse PFC, we performed tLTP experiments in L2/3 and L6 of human temporal and fronta...
(Fig.1b–g) suggesting the specific activity of SACs conferred this effect. APB also had no effect (Fig.1b–g) from P3 to P9, further supporting the specific role of cholinergic activity in driving angiogenesis from P3 to P9 and consistent with the prior data on SAC reduction and ...