latrophilin-2的发现及其在血流感知、血管发育和心血管疾病中的作用,对细胞生物学和遗传学研究具有重要意义。首先,这一发现为我们理解血管如何响应流动变化提供了新的视角。血流变化是血管发育和重塑的重要调控因素,而latrophilin-2的发现揭示了这一过程中的关键分子机制。通过感知血流变化,latrophilin-2能够调节血管...
Latrophilin-2 (Lphn2), an adhesive GPCR (G protein-coupled receptor), was found to be a specific marker of cardiac progenitors during the differentiation of pluripotent stem cells into cardiomyocytes or during embryonic heart development in our previous studies. Its role in adult heart ...
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latrophilin-3译文 latrophilin-3是一种蛋白质,它是由LPHN3基因编码的。在人体中,latrophilin-3主要表达在中枢神经系统中,尤其是在大脑和脊髓中。这种蛋白质在神经元之间的信号传导中起着重要作用。 关于latrophilin-3的译文,根据一般的生物学规则,它的译文应该是一个特定的氨基酸序列,这个序列是由LPHN3基因...
Focusing on parahippocampal circuitry, we find that latrophilin-2 (Lphn2; gene symbol ADGRL2) is specifically enriched in interconnected subregions of the medial entorhinal cortex (MEC), presubiculum (PrS), and parasubiculum (PaS). Retrograde viral tracing from the Lphn2-enriched region of ...
Here, we found that the adhesion GPCR latrophilin-2 (LPHN2) is a TGF-尾-independent receptor of LRG1. By interacting with LPHN2, LRG1 promotes both angiogenic and neurotrophic processes in mouse tissue explants under hyperglycemic conditions. Preclinical studies in a diabetic ED mouse model ...
Here, we investigated the functioning of a cardiomyogenic cell-surface marker, latrophilin-2 (LPHN2), an adhesion G-protein-coupled receptor, in cardiac differentiation. LPHN2 was selectively expressed in cardiac progenitor cells (CPCs) and cardiomyocytes (CMCs) during mouse and human pluripotent...
LPHN2 (latrophilin 2)doi:10.4267/2042/38040J HeighwayJean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher)
Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctionsdoi:10.1038/s44318-024-00142-0Tanaka, KeiichiroChen, MinghaoPrendergast, AndrewZhuang, ZhenwuNasiri, AliJoshi, DivyeshHintzen, JaredChung, MinhwanKumar, Abhishek...
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