the p.G376D mutation had a particularly rapid progression, from onset to death in less than 1.5 years [52]. p.G298S mutation is also considered to be short-lived [55], whereas the p.A315T mutation had a longer disease course of 8–10 ...
52 Nonaka A, Toyoda T, Miura Y, Hitora-Imamura N, Naka M, Eguchi M et al. Synaptic plasticity associated with a memory engram in the basolateral amygdala. J Neurosci 2014; 34: 9305–9309. 53 Humeau Y, Herry C, Kemp N, Shaban H, Fourcaudot E et al. Dendritic spine heterogeneity ...
Yasuchika A,Yuzuru T,Kazuhisa T,et,al.Sensory innervation of the lateral portion of the lumbar intervertebral disc in rats. SPINE . 2004Aoki Y, Takahashi Y, Takahashi K, et al. Sensory innervation of the lateral portion of the lumbar intervertebral disc in rats. Spine J 2004;4:275-80....
different types of neurons can be labeled by the expression of calcium indicators, which have a high detection rate for single action potentials [71]. In awakehSOD1G93Amice, motor neuron activity was monitored by expressing calcium indicator GCaMP6s [27]. Although...
In HD cortex, OPTN is seen in neuronal intranuclear inclusions co-labeled with ubiquitin [4]. This protein participates in multitasking cytosolic protein process involved in protein trafficking, maintenance of the Golgi complex, and exocytosis [4]. ALS12 is inherited in an autosomal recessive manner...
clear and specific signals were produced for each cRNA probe. Equivalent reaction intensity was found for NPY and 5-HT2C mRNA single detection using HS-TSA-FISH and for NPY also using MS-TSA-FISH. NPY mRNA detection using LS-TSA-FISH labeled cells less intensely and was therefore not used ...
In the 9 patients in whom the MSCs were labeled with ferumoxides, MRI of the brain and whole spine was performed at 24 to 48 hours and at 1 to 3 months after injection of MSCs. Hypointense signals in T2-weighted images, indicating the presence of ferumoxides-positive cells, were ...
In the 9 patients in whom the MSCs were labeled with ferumoxides, MRI of the brain and whole spine was performed at 24 to 48 hours and at 1 to 3 months after injection of MSCs. Hypointense signals in T2-weighted images, indicating the presence of ferumoxides-positive cells, were ...
Nucleic acid was labeled using DAPI. Scale bar is 10 μm. The percentage of 66 positive (66 +) and 66 negative (66 -) cells with SGs is shown; n = 4, −/+ s.e.m. Number of cells quantified: 66 R - (1243); 66 R + (818); Student’s t-test. B HeLa Kyoto ...
MC APs in presence or absence of ACh (1 mM) (orange and black traces). Bath application of ACh did not lead to a depolarization of the presynaptic pyramidal neuron (Ctrl. −59.85 ± 5.422 mV, ACh −59.56 ± 5.067 mV, pairedt-test, two-tailed,p = 0.3904;...