Abstract Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of αvintegrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular ...
Abstract Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of αvintegrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular ...
Latent forms of TGF-beta: molecular structure and mechanisms of activation. K Miyazono and C-H. Heldin, " Latent Forms of TGF-β : molecular structure and mechanisms of activation ", Ciba Foundation Symposium 157, 81-92 (... K Miyazono,CH Heldin - 《Ciba Foundation Symposium》 被引量:...
Latent forms of TGF-beta: molecular structure and mechanisms of activation. Ciba Found Symp, 1991; 157:81-9.Miyazono, K, Heldin, C-H Latent forms of TGFβ: molecular structure and mechanisms of activation. In: Bock, GR, Marsh, J eds. (1991) Clinical Applications of TGFβ. Wiley, ...
proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be so...
LTBP-1 promotes activation by anchoring to the ECM and creating traction when LAP is bound by cell surface integrins, and this traction can deform LAP and release the active growth factor [15], [16], [17]. LTBPs may also have roles in other TGFβ activation processes though these ...
Cardiovascular mechanical stresses trigger physiological and pathological cellular reactions including secretion of Transforming Growth Factor β1 ubiquitously in a latent form (LTGF-β1). While complex shear stresses can activate LTGF-β1, the mechanisms underlying LTGF-β1 activation remain unclear. We...
Latent TGF-β structure and activation. to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins... M Shi,J Zhu,R Wang,... - 《Nature》 被引量: 715发表: 2011年 Bone abnormalities in latent...
Latent-TGF-β: An overview Transforming growth factor-beta (TGF-beta) plays multiple homeostatic roles in the regulation of inflammation, proliferation, differentiation and would hea... David A. Lawrence 被引量: 0发表: 2001年 Latent TGF-β structure and activation. Transforming growth factor (TGF...
Since TGF-β has been associated with the pathogenesis of numerous diseases, the various mechanisms of activation of L-TGF-β in context offer the possibility of controlling TGF-β activity localized to the organ of involvement and to a more specific disease process....