Latent TGF-β binding protein-1, -3 and -4 bind latent TGF-β. TGF-βs are normally secreted as latent complexes, consisting of the mature TGF-β dimer non-covalently bound to its processed propeptide dimer plus a latent TGF-β binding protein. The latent TGF-β binding protein is ...
Latent TGFβ binding proteins Extracellular matrix Latency associated protein TGFβ activation Introduction The LTBPs are a group of extracellular multi-domain proteins with several unique biological properties. They contain a number of modular domains including tandem arrays of calcium binding (cb) EGF ...
We previously reported that latent TGF-尾 binding protein 2 (LTBP-2), a microfibril-associated protein, is required for forming stable microfibril bundles in ciliary zonules. However, it was not understood whyLtbp2null mice only showed an eye-specific phenotype, whereas LTBP-2 is abundantly ...
et al. Latent TGF-βbinding protein-2 is essential for the development of ciliary zonule microfibrils. Hum Mol Genet 23, 5672–5682 (2014). 14. Gibson, M. A. et al. Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms...
摘要: •We describe structures and interactions of the four latent transforming growth factor beta binding proteins (LTBP) proteins.•The biological functions of the four LTBPs关键词: Latent TGFβ binding proteins Extracellular matrix Latency associated protein TGFβ activation ...
Latent TGF-beta binding proteins (LTBPs) are components of the extracellular matrix (ECM). They belong to the fibrillin/LTBP-superfamily, and are high molecular weight glycoproteins characterized by EGF-like repeats and 8-Cys repeats. Most LTBPs associate with the small latent forms of TGF-beta...
Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1 Transforming growth factor-βs (TGF-β) are secreted as inactive complexes containing the TGF-β, the TGF-β propeptide, also called the latency-associated... Justin,P.,Annes,... - 《Journal...
Latent TGF-β binding protein LTBP-2 decreases fibroblast adhesion to fibronectin. Latent TGF-beta binding protein LTBP-2 decreases fibroblast adhesion to fibronectin. J Cell Biol. 2003; 163 :1363–74.Hyytiainen, M. and Keski-Oja, ... Hyytiäinen,Marko,Keski-Oja,... - 《Journal of ...
latent TGF-beta-binding protein 3 information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
Latent TGF-{beta} binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5 [Cell Biology] Elastic fiber assembly requires deposition of elastin monomers onto microfibrils, the mechanism of which is incompletely understood. Here we show that latent TGF-尾 binding protein 4 (...