Late-life depression (LLD) is one of the most common mental disorders among the older adults. Population aging, social stress, and the COVID-19 pandemic have significantly affected the emotional health of older adults, resulting in a worldwide prevalence of LLD. The clini...
抑郁症是老年人常见的精神障碍之一。老年抑郁症 (late life depression,LLD)广义上指年龄在60岁以上的抑郁症病人,狭义上是指首次起病年龄在60岁之上的抑郁症病人,以持久的情绪低落为主要临床症状的一种精神障碍性疾病,其危害性不容忽视,如不及时诊治将严重影响老年人生活质量,导致老年人精神残疾,抑郁严重的老...
Late-life depression (LLD) is both a prevalent and life-threatening disorder, affecting up to 13.3% of the elderly population. LLD can be difficult to identify because patients mainly consult their general practitioner (GP) for somatic complaints. Moreover, patients may be hesitant to express the...
Depression advances biological aging evidenced by shorter telomere length, accelerated brain aging and advanced epigenetic aging1. Depression increases the risk of obesity, frailty, diabetes, cognitive impairment, and mortality2,3. A body of literature links depression with cardiac, cerebrovascular, and p...
Major depression in the elderly is a heterogeneous disorder that presents with a constellation of cognitive and affective symptoms. Neuroimaging has helped elucidate the contributions of dorsal-cognitive and ventral-affective brain regions to the pathophysiology of late-life depression (LLD). Functional co...
fMRIDistinct hippocampal functional network correlates in late-life depression and MCI.Late-life depression and MCI interact on hippocampal functional network level.Hippocampal functional network correlates with neuropsychological measures.Novel insights into functional network vulnerability underlying depression and...
Late-life depression (LLD) carries additional risk for suicide, medical comorbidity, disability, and family caregiving burden. Although response and remission rates to pharmacotherapy and electroconvulsive therapy are comparable with those in midlife depression, relapse rates are higher, underscoring the ...
This narrative review aimed to explore the existing knowledge in order to examine the multiple forms of late-life depression (LLD) within a non-neurodegenerative or a neurodegenerative context, in particular Alzheimer's disease (AD). This review will first provide information about different pathogenic...
late life. Another personality characteristic associated with resilience is grit, defined as “perseverance and passion for long-term goals” in the face of setbacks35. A recent study of 337 adults with LLD found that grit was associated with decreased severity of depression, apathy, and anxiety...
However, important limitations to these studies call for controlled trials of hearing remediation as a treatment for late-life depression (LLD). We conducted the first double-blind randomized clinical trial utilizing rigorous control groups, objective documentation of compliance of the hearing aid, ...