Late-life depressionAlzheimer’s differential diagnosticFluency taskMeta-analysisThe cognitive complaints encountered in late-life depression (LLD) make it difficult to distinguish from amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) based on an analysis of neurocognitive disorders....
Late-life depression ranges from mild to severe and can lead to significant physical and social limitations. Up to one-third of patients with medical disorders also suffer from depressive symptoms. Differential diagnosis of depression is often confounded by medical conditions that impair cognitive functi...
Late-life depression (LLD) is associated with an increased risk of developing dementia; however, it is not known whether individuals with a history of LLD exhibit a more rapid rate of cognitive decline. We aimed to determine whether those with LLD experienced faster cognitive decline compared with...
Depression predisposes to medical illnesses and advances biological aging indicated by shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical illnesses also increase the risk of late-life depression. The reciprocal relationships of depression with aging-related and disease-rel...
(3-5) Late-life depression is both underrecognized and undertreated. The impact of medical comorbidity may mask depressive symptoms. Social isolation, recent bereavement, and cognitive impairment as well as the stigma of depression and the belief that it is a normal part of aging, can also ...
Most importantly, late-life depression that is undiagnosed or untreated may lead to a higher risk of morbidity; a decrease in cognitive, physical, and social functioning; general self-neglect and an increase of the dependence by the others.16,17 Because depression appears to ...
99mTc-HMPAO single photon emission tomography in late life depression: a pilot study of regional cerebral blood flow at rest and during a verbal fluency task 来自 NCBI 喜欢 0 阅读量: 30 作者:MP Philpot,S Banerjee,H Needhambennett,DC Costa,PJ Ell ...
Often patients in the early stages of (AD), (FTD), and late-life can be difficult to differentiate clinically. Although subtle cognitive distinctions exist between these disorders, noncognitive behavioral phenomenology may provide additional discriminating power. In 19 subjects with AD, 19 with FTD,...
Furthermore, patients who eventually respond to treatment will likely take longer to do so (ie 8–12 weeks) compared with patients with depression during other stages of life (Reynolds and Kupfer, 1999). For these reasons, much of LLD neuroimaging-based research has sought to identify markers ...
What are the causes of late-life depression? Psychiatr Clin North Am. 2013;36:497–516. Article PubMed PubMed Central Google Scholar Schaakxs R, Comijs HC, van der Mast RC, Schoevers RA, Beekman ATF. Penninx BWJH. risk factors for depression: differential across age? Am J Geriatr ...