Late-onset late-life depression (LLD, depression with an age of onset above 60 years) appears to differ from depression with early onset in its association with cerebral small vessel disease, beta-amyloid and tau deposition, and neurodegenerative processes. Multimodality imaging (SPECT, PET, MRI)...
Depression is associated with an increased risk of dementia [1]. Due to the heterogeneity of late-life depression (LLD), many researchers have attempted to classify its phenotypes [2]. Among these, late-onset depression (LOD) and early-onset depression (EOD) distinguished by the age of first...
This study was conducted to clarify patterns of cortico-limbic volume abnormalities in late life depression (LLD) relative to non-depressed (ND) adults matched for amyloid β (Aβ) deposition and to evaluate the relationship of volume abnormalities with cognitive performance. Participants included 116...
Depression predisposes to medical illnesses and advances biological aging indicated by shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical illnesses also increase the risk of late-life depression. The reciprocal relationships of depression with aging-related and disease-rel...
13-16 Childhood adversity is also associated with a number of adverse health outcomes in adulthood, including putative dementia risk factors such as cardiovascular disease, stroke, diabetes, and depression,17 suggesting a potentially important role in late-life cognitive and brain health. The impact ...
This magnetoencephalography study aimed at characterizing age-related changes in resting-state functional brain organization from mid-childhood to late adulthood. We investigated neuromagnetic brain activity at rest in 105 participants divided into three
Regional distribution of amyloid deposition and grey matter atrophy in late‐life depressionDepression is associated with a risk of developing dementia and is hypothesized to enhance (pathological) brain aging. Previously we reported that amyloid burden in late﹍ife depression (LLD) did not differ ...
Conclusions Amyloid accumulation is elevated in late life depressed subjects which may reflect the pathological correlate for increased conversion rates to dementia in those patients. Highly depressed patients revealed pronounced amyloid-load in depression- related frontal regions.Matthias Brendel...
tau-PETMRIObjective To investigate whether tau accumulation is higher in late life depression (LLD) compared to non-depressed cognitively unimpaired (CU) older adults. To situate these findings in the neurodegeneration model of LLD by assessing group differences in tau and grey matter volume (GMV)...
As the population ages, focus is increasing on management of late-life depression.1 Major depressive disorder (MDD) is common in older populations worldwide and can decrease the quality of life, as well as worsen medical outcomes, decrease physical, cognitive and social functioning, and increase ...