Late-onset late-life depression (LLD, depression with an age of onset above 60 years) appears to differ from depression with early onset in its association with cerebral small vessel disease, beta-amyloid and tau deposition, and neurodegenerative processes. Multimodality imaging (SPECT, PET, MRI)...
Depression is associated with an increased risk of dementia [1]. Due to the heterogeneity of late-life depression (LLD), many researchers have attempted to classify its phenotypes [2]. Among these, late-onset depression (LOD) and early-onset depression (EOD) distinguished by the age of first...
Image from a Johns Hopkins Medicine study showing PET scans from brains of people with and without late-life depression. The brains of patients with late-life depression show more yellow to red regions (scans on the left), indicating higher amyloid beta protein levels, and more blue regions (...
Depression predisposes to medical illnesses and advances biological aging indicated by shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical illnesses also increase the risk of late-life depression. The reciprocal relationships of depression with aging-related and disease-rel...
Lifespan brain activity, β-amyloid, and Alzheimer's disease J. (2013). The effect of amyloid beta on cognitive decline is modulated by neural integrity in cognitively normal elderly . Alzheimers Dement. 9 , 687... WJ Jagust,EC Mormino - 《Trends in Cognitive Sciences》 被引量: 427发表:...
Pittsburgh compound B (PiB) radiotracer for positron emission tomography (PET) imaging can bind to different types of amyloid-β plaques and blood vess
Amyloid-β1–42 immunoreactivity was observed intraneuronally in the entire cholinergic population in basal forebrain quite selectively, early in adult life and regardless of age. Increases in the prevalence of intermediate and large molecular weight soluble oligomer species were observed in aged and ...
This magnetoencephalography study aimed at characterizing age-related changes in resting-state functional brain organization from mid-childhood to late adulthood. We investigated neuromagnetic brain activity at rest in 105 participants divided into three
As the population ages, focus is increasing on management of late-life depression.1 Major depressive disorder (MDD) is common in older populations worldwide and can decrease the quality of life, as well as worsen medical outcomes, decrease physical, cognitive and social functioning, and increase ...
Systemic infections lead to the development of “sickness behaviour”, clinical features of which include fever, depression, apathy, self-reported ill health and attentional deficits [18]. At least in animal models this is, in part, mediated by the transient production of pro-inflammatory cytokines...