Late-onset late-life depression (LLD, depression with an age of onset above 60 years) appears to differ from depression with early onset in its association with cerebral small vessel disease, beta-amyloid and tau deposition, and neurodegenerative processes. Multimodality imaging (SPECT, PET, MRI)...
Late-life depression (LLD) is associated with an increased risk of developing dementia; however, it is not known whether individuals with a history of LLD exhibit a more rapid rate of cognitive decline. We aimed to determine whether those with LLD experienced faster cognitive decline compared with...
Even so, we did not find a difference in amyloid deposition between LOD and HC groups. Our findings were consistent with several studies showing no association between amyloid deposition and major depression in late-life, suggesting a non-amyloid pathway to dementia [27, 44, 45]. Despite ...
Image from a Johns Hopkins Medicine study showing PET scans from brains of people with and without late-life depression. The brains of patients with late-life depression show more yellow to red regions (scans on the left), indicating higher amyloid beta protein levels, and more blue regions (...
lifetime history of depression had amyloid accumulation in brain regions related to mood regulation112. Depression is associated with a high conversion rate of amnestic mild cognitive impairment (aMCI) to Alzheimer’s dementia113. Patients with aMCI and history of major depression had higher Aβ ...
Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain 2007; 130: 2837–2844. Article Google Scholar Butters MA, Klunk WE, Mathis CA, Price JC, Ziolko SK, Hoge JA et al. Imaging Alzheimer pathology in late-life depression with PET ...
Regional distribution of amyloid deposition and grey matter atrophy in late‐life depressionDepression is associated with a risk of developing dementia and is hypothesized to enhance (pathological) brain aging. Previously we reported that amyloid burden in late﹍ife depression (LLD) did not differ ...
amyloid-betaC-reactive proteinflorbetapir PETimmune systeminflammationBackground: Although inflammation has been implicated in the pathogenesis of Alzheimer's disease, the effects of systemic inflammation on brain amyloid deposition remain unclear.Walker, Keenan A....
Pittsburgh compound B (PiB) radiotracer for positron emission tomography (PET) imaging can bind to different types of amyloid-β plaques and blood vess
No elder reported any subjective sleep or cognitive (e.g., memory impairment) problem, and all had an active personal and social life, did not take any psychotropic drug and were thoroughly screened for sleep habits, depression, anxiety and objective signs of pathological cognitive decline. Based...