Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug. Evidence for chronic encephalopat... BACKGROUND AND PURPOSE: It has been recognized that postischemic pharmacological interventions may delay the evolution of neuronal damage rather than...
The effects of vincristine given intravenously on deep and superficial body temperature were assessed in rats kept at ambient temperature within the thermoneutral range. Vincristine (0.5 and 1 mg/kg i. v.) produced a gradual but marked hypothermic response which was dose-dependent, reached its max...
Key results: Female, not male, adolescents developed tolerance to the hypothermic effects of THC inhalation in the first week of repeated exposure despite similar plasma THC levels. Each sex exhibited tolerance to THC hypothermia in adulthood after repeated adolescent THC; however, enhanced potency ...
Anticonvulsant effects of the BK-channel antagonist paxilline. Previously we have found that seizures themselves induce a gain-of-function in BK channels that is associated with elevated excitability in neocortical ... JJ Sheehan,BL Benedetti,AL Barth - 《Epilepsia》 被引量: 90发表: 2009年 Cortica...
Effects of glycyrrhizin on the systemic inflammatory response and neuroinflammation following surgery.aGlycyrrhizin (10, 20, or 40 mg/kg, once) were administered i.p. 30 min before and 12 h after surgery, and the serum HMGB1 concentration was measured using ELISA on postoperative day 1 (n ...
of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic...
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In the present study, we compared the time courses and dose-response relationship for the ability of i.c.v. injected neurotensin and JMV 449 to elicit hypothermia and analgesia (tail-flick test) in the mouse. The results show that the pseudopeptide analogue behaved as a highly potent and ...
Thus, the present study demonstrates in the mice that oral intake of CAP causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity, and moreover activates the brain circuits controlling thermoregulation and metabolism. Copyright 2019 Elsevier Inc. All ...