Experience with 240+ biologic programs enables us to provide scientific and technical expertise We have demonstrated scientific and regulatory expertise, with ~25 BLA submissions completed over the past five years. We have worked on over 1100 molecules over the past five years ...
C. Fundamental molecular mechanism for the cellular uptake of guanidinium-rich molecules. J. Am. Chem. Soc. 136, 17459–17467 (2014). Article CAS PubMed PubMed Central Google Scholar Duchardt, F., Fotin-Mleczek, M., Schwarz, H., Fischer, R. & Brock, R. A comprehensive model for ...
New Evo 1 GHz NMR fits in 1 story building, uses 70% less helium. Ideally suited to characterise complex molecules such as RNA, oligonucleotides, peptides, antibodies and more! Position your company at the heart of the global Pharma industry with a CPHI Online membership Your products and sol...
Biologics are forecast to account for roughly 60% of revenue growth through 2010 for Big Pharma as growth in small molecules slows. The author analyzes the factors driving demand and how the technology life cycles of these two sectors will affect market
large molecules, minor variations in production processes – such as the control conditions, expression environments, and the purification and preparation methods of host cells – may lead to huge differences between biosimilars and reference drugs in terms of purity, ...
percentage of the drug in the plasma that is bound. For instance, if a drug has a PPB of 90%, it means that 90% of the drug molecules present in the plasma are attached to plasma proteins, leaving only 10% free and active. There are records of 1,262 molecules in the PPB datasets...
Scientific Large Language Models: A Survey on Biological & Chemical Domains - GitHub - HICAI-ZJU/Scientific-LLM-Survey: Scientific Large Language Models: A Survey on Biological & Chemical Domains
Mechanistic studies on release of large and small molecules from biodegradable SiO2. Int J Pharma 2007; 336: 382-390.Viitala R, Jokinen M, Rosenholm JB. 2007. Mechanistic studies on release of large and small molecules from biodegradable SiO2. Int J Pharm 336(2):382-390....
Semaglutide and liraglutide are structurally similar molecules with high selectivity for the GLP-1 receptor, though there are some pharmacologic differences between the two – notably, liraglutide has a higher steady state concentration and greater receptor binding affinity than semaglutide, while ...
ChEMBL (https://www.ebi.ac.uk/chembl) is a large-scale, open-access drug discovery resource containing information about bioactive molecules, their interaction with targets (e.g.molecular, cell- or tissue-based) and their biological effects1–4. It aspires to the FAIR data management princip...