CDR132L improves systolic and diastolic function in a large animal model of chronic heart failuredoi:10.1093/eurheartj/ehaa791Sandor BatkaiCelina GenschelJanika ViereckSteffen RumpChristian BrTobias BorchertDenise TraxlerMartin RiesenhuberAndreas Spannbauer...
A knowledge gap persists between machine learning (ML) developers (e.g., data scientists) and practitioners (e.g., clinicians), hampering the full utilization of ML for clinical data analysis. We investigated the potential of the ChatGPT Advanced Data Analysis (ADA), an extension of GPT-4,...
calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP), and age [24]. Blood pressure measurements were obtained using a standardized protocol, where the average of three consecutive readings taken by trained professionals after a five-minute rest...
The association of epilepsy with other neurological diseases and psychiatric disorders in total and sex-specific populations. The model for stroke was adjusted for age at baseline, sex, ethnicity, systolic blood pressure, and diastolic blood pressure. The model for other disorders was adjusted for ag...
31and may be subjected to demand characteristics effects32,33. Future research using physiological assessments of the autonomic nervous system (for example, assessment of catecholamines, assessment of the autonomic nervous system via skin conductance, cortisol, heart rate and systolic and diastolic blood...
Post hoc test was used for pairwise comparison and the Bonferroni was used for adjusting the p-value. The Spearman correlation test was used in the correlation analysis. Correlations between macular vascular density and age, sex, diastolic pressure, systolic pressure, Body mass index (BMI), AL...
Drug repositioning offers numerous advantages, such as faster development timelines, reduced costs, and lower failure rates in drug development. Supervised machine learning is commonly used to score drug candidates but is hindered by the lack of reliable negative data—drugs that fail due to in...
compared to the medium control, including increases in cardiac contractility and left ventricular ejection fraction (LVEF) and prevention of worsening ventricle geometry, manifested by the significant decrease in end-systolic diameter (ESD) and both end-diastolic (EDV) and end-systolic (ESV) volume....
Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine
shown to protect the heart against IRI in the experimental setting3,12, only few of them have succeeded in translating their findings into positive proof-of-concept clinical trials demonstrating either reduction in myocardial IS, or improvement in left ventricular systolic function18,19,20,21,22. ...