Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol:doi:10.1177/1040638717743280Oscar R. Sierra MatizJuliana SantilliLeticia A. AnaiMaria C. L. Da Silva...
canine nodal diffuse large B‐cell lymphomaclinical signsprognosissubstagesurvivaltreatment responseIn humans B﹕ymptoms refer to systemic symptoms of lymphoma such as fever, weight loss, and night sweats and influence the prognosis of patients. In canine lymphoma, substage B is used to describe ...
Flow Cytometric Characterization and Clinical Outcome of CD4+ T-Cell Lymphoma in Dogs: 67 Cases BackgroundCanine T-cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 T... R P.,Avery,J.,... - 《Journal of Vet...
The anti-histaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylas... SummaryCyproheptadine, an inhibitor of the H1 histamine receptors, has recently shown activity in models of leukaemia and myeloma, presumably thro...
Current Controversies in Melanoma Treatment A workhorse reconstruction option for wide excision defects, particularly in extremities, is the keystone flap. There are alternative surgical approaches to ... C Temple-Oberle,C Nicholas,P Rojas-García - 《Plastic & Reconstructive Surgery》 被引量: 0发表...
treatment naiveWhile current lymphoma therapies induce remission in most dogs, drug-resistant relapse is common, creating a need for novel agents. Rabacfosadine (RAB), a double prodrug of the acyclic nucleotide phosphonate 9-(2-phosphonylmethoxyethel) guanine (PMEG), preferentially targets lymphoma...
Curran KM, Schaffer PA, Frank CB, Lana SE, Hamil LE, Burton JH, Labadie J, Ehrhart EJ, Avery PR. BCL2 and MYC are expressed at high levels in canine diffuse large B-cell lymphoma but are not predictive for outcome in dogs treated with CHOP chemotherapy. Vet Comp Oncol. 2017;15(4)...
Dogs with Diffuse Large B-Cell Lymphoma (DLBCL) benefit from the addition of active immunotherapy to traditional chemotherapy. We hypothesized that immune cells within neoplastic lymph nodes (LNs) may play a role in the tumor pathobiology and treatment response.Martini, ValeriaAresu, LucaRiondato, ...
Canine diffuse large B‐cell lymphoma (DLBCL), the most common hematologic malignancy of dogs, is associated with poor overall survival. The lack of conventional chemotherapies with sustainable efficacy warrants investigation of novel therapies. Pevonedistat (MLN4924) is a potent and selective small ...
Objective The objective of this pilot study is to evaluate the accuracy of the Lugano staging system, compared to the WHO, in predicting first remission duration (FRD) in dogs. Thirty dogs with multicentric large B cell lymphoma, staged according to both systems, and treated with a standard ...