本文主要介绍LAG-3。 (数据来源:PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity) 相对于亲本抗体BI127,IBI323对PD-L1的结合亲和力保持不变。 BI127在Fc部分引入LALA突变(LALA, L234A, L235A),降低了Fc介导的抗体依赖细胞介导的毒性(ADCC)和补体介...
Antibody 克隆号 BLR028F 抗原 Recombinant protein representing the extracellular domain of human Lymphocyte activation gene 3 (LAG3, residues 23-450). 查看免疫原 偶联物 Unconjugated 形式 Liquid 浓度 1 mg/mL 纯化类型 Antigen affinity chromatography 保存液 BBS, pH 8.2 内含物 ...
BACKGROUNDLAG3 (Lymphocyte activation gene3), also known as CD223, is a member of the immunoglobulin superfamily (IgSF). The mature LAG3 protein is a 496 amino acid (aa) membrane protein with a 421 aa ...
[6] Wang J , Sanmamed M F , Datar I , et al.Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3[J].Cell, 2018, 176(1-2). [7] Johnson M L , Patel M R , Cherry M , et al. Safety ofBI 754111, an anti-LAG-3 monoclonal antibody (mAb), in combination...
CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), eFluor™ 450, eBioscience™ CNY 2,166.00 Unit Size : 100 µg 添加到购物车 Catalog # 14-2231-82 Invitrogen CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), eBioscience™ CNY 1,883.00 Unit Size : ...
Applications for LAG-3 Antibody (1009614) [PE] Application Recommended Usage CyTOF-ready Optimal dilutions of this antibody should be experimentally determined. Flow Cytometry Optimal dilutions of this antibody should be experimentally determined. Application Notes Optimal dilution of this antibo...
Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with advanced hepatocellular carcinoma who had failed prior targeted therapy and/or immunotherapy: An open-label, single-arm, phase 1/2 dose-escalation and expansion study. 第一作者及研究PI:任正刚,复旦大学附属中山医院 研究背景 靶向PD...
[7] Johnson M L , Patel M R , Cherry M , et al. Safety ofBI 754111, an anti-LAG-3 monoclonal antibody (mAb), in combination with BI754091, an anti-PD-1 mAb, in patients with advanced solid tumors[J]. Journal ofClinical Oncology, 2020, 38(15_suppl):3063-3063....
Product Specific Notices for LAG-3 Antibody (631501) [DyLight 550] DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for...
Dazzle™ 594 anti-human CD223 (LAG-3) Antibody-PE详细如下: 369331 Dazzle™ 594 anti-human CD223 (LAG-3) Antibody-PE Dazzle™ 594 抗人 CD223 (LAG-3)荧光标记PE 抗体 25 tests ￥2,900.00 369332 Dazzle™ 594 anti-human CD223 (LAG-3) Antibody-PE Dazzle™ 594 抗人 CD223 (...