(Kla), on core histones. However, the impact of lactylation on biological processes of tumour cells remains largely unknown. Here we show a global lactylome profiling on a prospectively collected hepatitis B virus-related hepatocellular carcinoma (HCC) cohort. Integrative lactylome and proteome ...
The global lactylome revealed the landscape of lactylated sites and proteins in the CD4(+) T cells of normal and EAU mice. Specifically, hyperlactylation of Ikzf1 at Lys(164) promoted T(H)17 differentiation by directly modulating the expression of T(H)17-related genes, including Runx1, ...
Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying Th17 Differentiation in Lupus Nephritisdoi:10.1681/ASN.2024ygrd8hadMingyang ZhangArmy Medical University, ChongQing, ChongQing, China .American Society of NephrologyJournal of the American Society of Nephrology...