Lactoferrin (Lf) is an iron binding glycoprotein of the transferrin family that is expressed in most biological fluids and is a major component of mammals’ innate immune system. Its protective effect ranges from direct antimicrobial activities against a
Susana A González-Chávez,Sigifredo Arévalo-Gallegos,Quintín Rascón-Cruz.Lactoferrin: structure, function and applications. International Journal of Antimicrobial Agents . 2009Suzuki YA, Lönnerdal B. 2010. Lactoferrin: structure, functions, and applications. Funct. Food Rev. 2 : 69-79 .Shima...
1990). One consequence of this is that the open apo form is more susceptible to denaturation and proteolytic digestion than is the Fe-bound (holo) form. Iron is released by lowering the pH, but in lactoferrin the degree of stabilization of the lobe structure is greater than in transferrin,...
The biologic functions of lactoferrin are then comprehensively reviewed, including antimicrobial, antiviral, antiinfl ammatory, immunomodulatory, and anticancer activities, as well as other functions, such as growth stimulation of probiotic bacteria, regulation of bone homeostasis, antiadipogenic effects, ...
Thus, lactoferrin has a wide variety of biological functions, many of which do not appear to be connected with its iron binding ability (Brock, 2002). Structure and properties of lactoferrin Lactoferrin is a glycoprotein with a molecular weight of about 80 kDa, which shows high affinity for...
Theglycoproteinlactoferrinwas first described as an iron-binding protein in breast milk and shows immune-modulatory functions[185,186]. The human recombinant lactoferrin,talactoferrin, is given orally, and is able to recruit immature dendritic cells (DCs) into the gut-associated lymphoid tissue, where...
Legrand D, Pierce A, Elass E et al (2008) Lactoferrin structure and functions. Adv Exp Med Biol 606:163–194 Article Levay PF, Viljoen M (1995) Lactoferrin: a general review. Haematologica 80:252–267 Leveugle B, Spik G, Perl DP et al (1994) The iron-binding protein lactotransferrin...
Its basic structure consists of a single polypeptide chain with two globular lobes and an iron-binding site. This compound is soluble in water. Lactoferrin is generally considered safe for consumption and use in various applications. It has been found to have antimicrobial, anti-inflammatory, and ...
Legrand D, Pierce A, Elass E, Carpentier M, Mariller C, Mazurier J (2008) Lactoferrin structure and functions. Bioact Components Milk 606:163–194 ArticleCASGoogle Scholar Abd El Hafez SM, Ismael AB, Mahmoud MB, Elaraby A-KA (2013) Development of new strategy for non-antibiotic therapy...
Brock et al, “Interaction of Lactoferrin with Mononuclear and Colon Carcinoma cells,” Lactoferrin—Structure and Function, T.W. Hutches, S.V. Rumball and B. Lonnerdal. New York, Plenum PRess: pp. 157-169. (1994). Bronte, “Genetic vaccination for the active immunotherapy of cancer,”...