Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Critical care medicine. 2015;43:567-73.Casserly, B.; Phillips, G.S.; Schorr, C.; Dellinger, R.P.; Townsend, S.R.; Osborn, T.M.; Reinhart, K.; Selvakumar, N.; Levy, M...
Hence, relying solely on the lactate levels may be inadequate. In addition, evidence shows that the lactate clearance at the first hours was associated with an improvement of outcome in severe sepsis and septic shock patients and was proposed to guide treatment9,19,20,21,22,23. Reduced lactate...
The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has been shown to result in significantly lower mortality, its use remains controversial. Ther...
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis. The present study demonstrated a novel role of lactate in HMGB1 lactylation and ace...
causes for elevated blood lactate levels in patients with ami include increased glycolysis, tissue hypoperfusion, insulin resistance, haemodynamic impairment, myocardial infarction, blood glucose values, reduced ability of the body to remove lactate, uncontrolled diabetes stimulating the production of fatty ...
Lactate-Induced ER Mg2+ Depletion and Subsequent Mitochondrial Mg2+ Uptake in Multiple Cell Types, Related to Figure 1 (A) Representative trace demonstrating changes in fluorescence intensity values of Fluo-4-AM in HeLa cells following stimulation with the GPCR agonist histamine. (B) Bar chart ...
The lactate dehydrogenase (LDH) to albumin ratio (LAR), expressed as LDH/albumin, is a recently proposed biomarker that shows promise in predicting outcomes in various disease states, including cancer, liver disease, and sepsis [4,5]. The LAR represents the ratio of LDH to albumin levels in...
Considering the strong relationship between hyperlactatemia, lactate kinetics, and mortality,3and the results of a recent study,4the Surviving Sepsis Campaign, proposes to guide hemodynamic resuscitation by repeated measurement of blood lactate levels every 2 to 4 hours until normalization.5However, per...
sepsis; thus, the serum lactate level on ICU day 1 was replaced by the initial lactate level, and imputation was done with the other 2 patients. Thus, Lac-SOFA ICU day-1 was analyzed with 1,174 patients. One-hundred fifty patients did not have serum lactate values for ICU day 2. ...
SepsisPredictMortalityPurpose Septic patients with hyperlactatemia have increased mortality rates, irrespective of hemodynamic and oxygen-derived variables. The aims of the study are the following: (1) to ascertain whether lactate clearance (LC) (percentage change in lactate over unit time) predicts ...