The review article presents a new look at the role of lactate in the human body. Lactate is known to have both positive and negative effects which depend on its concentration. Lactate concentrations up to 15 mM are optimal for the implementation of its positive effects, such as the ...
inflammatory microenvironment and highlights the essential role of lactate in the regulation of both acute and chronic inflammatory processes with the aim of providing a new perspective for the prevention and treatment of inflammatory diseases. lactate and lactate metabolism in the inflammatory ...
In subject area: Agricultural and Biological Sciences The lactate shuttle concept is based on the fact that cells that produce high amounts of lactate through glycolytic metabolism extrude this lactate to the extracellular matrix, after replenishing the NAD+ pool, from where it is taken up by othe...
recent years, the mysterious role of lactate has gradually been identified. in addition to representing a metabolic waste product, lactate is also involved in the growth and development of organs and in the coordination of vascular development and progenitor cell behaviour in the developing mouse ...
Rough feed material and foreign bodies may play a role in causing abrasions. Actino bacillus lignieresii then enters into deeper tissues, where it causes chronic inflammation and abscess formation. Lymphatic spread may occur, leading to abscessation of lymph nodes or infection of other organs. ...
The results of isotope tracer studies at the whole-body and tissue levels have clarified longstanding issues concerning metabolic regulation. In particular, the role of the mitochondrial reticulum1,2in lactate disposal has been identified. The reticulum lowers cellular [lactate] by oxidative disposal, ...
The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates ...
Increased blood lactate levels (hyperlactataemia) are common in critically ill patients. Although frequently used to diagnose inadequate tissue oxygenation, other processes not related to tissue oxygenation may increase lactate levels. Especially in crit
Isoform 1 (MCT1) is the predominant isoform in the oxidative fibers, whereas in the fast-twitch, least oxidative, fibers, isoform 4 (MCT4) plays a major role [39, 73]. Several studies have shown that the expression of MCT1 is upregulated by training [39, 1, 3, 48, 11]. ...
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