However, there are certain congenital disorders (inborn errors of metabolism) in which pyruvate is not converted to lactate. One example is pyruvate dehydrogenase deficiency. In these cases, pyruvate will accumulate, the blood level will be high, and the lactate to pyruvate ratio will be low. ...
Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-in-result-out POC platform is ...
18. Hussien R, Brooks GA Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Physiol Genomics 43: 255–264. 19. Manning Fox JE, Meredith D, Halestrap AP (2000) Characterisation of human monocarboxylate t...
Indeed, impairment of oxidative phosphorylation usually results in L/P ratios above 20 and ketone body ratios above 2, whereas a defect of the pyruvate dehydrogenase (PDH) complex results in low L/P ratios (around 10). When basal screening tests are inconclusive, the same test in CSF with ...
The activity of lactate dehydrogenase is, however, highest in those fibers that have the lowest volume density of mitochondria and the lowest number of capillaries per fiber area both in horses [31] as well as in other species [38, 20]. In horses these are usually the fast-twitch type ...
(TAT). TAT may be sep-arated into two intervals: 1) the time from test orderingto receipt of results; 2) the time from receipt of resultsto treatment [1]. The rapidity of POC lactate analysis isdue in part to the fact that whole blood is used, therebyobviating the need for ...
andmedicationbeforethecollectionofthesample.SpecimenrequirementsSamplesforthistestmustbecollectedatBiolabasthesamplemustbecentrifugedandtheplasmafrozenimmediatelyaftercollection.MethodologyD-lactateismeasuredbycentrifugalanalysisusingthespecificenzymeD-lactatedehydrogenase,whichdoesnotreactwithL-lactate[7].P.T.O.Turn...
Malaria Journal BioMed Central Research Open Access Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria Elizabeth A Ashley*1,2, Malek Touabi1,3, Margareta Ahrer3, Robert Hutagalung1, Khayae Htun3, Jennifer Luchavez4, ...
Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-in-result-out POC platform is ...