Lactate dehydrogenase(LDH) catalyzes the synthesis of lactate andpyruvatein a reversible reaction, and is commonly used as a biomarker of cell damage or death. Normal distribution ofLDHand itsisoenzymesin skeletal muscles of rats revealed that, in controls, LDH activity was found to be highest in...
Lactate dehydrogenase (LDH) is present in numerous cell types, including platelets, which have high LDH activity (Hule, 1966). Plasma LDH levels are routinely obtained to develop or refine a differential diagnosis. Significant elevations are seen in various malignancies, tissue necrosis, haemolytic ...
Twitter Google Share on Facebook lactate (redirected fromlactate shuttle) Thesaurus Medical Encyclopedia lac·tate1 (lăk′tāt′) intr.v.lac·tat·ed,lac·tat·ing,lac·tates To secrete or produce milk. [Latinlactāre, lactāt-, fromlac, lact-,milk; seelacto-.] ...
MECHANISM OF LACTATE DEHYDROGENASE Lactate dehydrogenase (EC 1.1.1.27) catalyzes the following reaction: Sign in to download full-size image In the reverse direction, this reaction represents the last step in anaerobic glycolysis and provides a means for regenerating NAD+ required for the reaction c...
Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD)
It is well known that high-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show that lactate dehydrogenase A (LDHA) prefe
The need for NADH reoxidation in the cytoplasm means that the formation of lactic acid is essential for anaerobic energy production. All muscle fibers contain the necessary enzyme lactate dehydrogenase. The activity of lactate dehydrogenase is, however, highest in those fibers that have the lowest ...
Human lactate dehydrogenase 5 (hLDH5) represents a promising anticancer target, particularly for the treatment of hypoxic tumors, where it is often hyperexpressed. In fact, by catalyzing the reduction of pyruvate to lactate, hLDH5 allows the survival of tumor cells under hypoxic conditions by ...
The lactate shuttle concept is based on the fact that cells that produce high amounts of lactate through glycolytic metabolism extrude this lactate to the extracellular matrix, after replenishing the NAD+ pool, from where it is taken up by other malignant oxidative cells that use this lactate as...
The abbreviations used are: ARE, A + U-rich element; AUBP, AU-rich sequence-binding proteins; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GM-CSF, granulocyte-macrophage colony-stimulating factor; LDH, lactate dehydrogenase; UTR, untranslated region; PBS, phosphate-buffered saline; NEPHGE, non...