The direction of rotation indicated enhancement of activity in the intact nigrostriatal system. However, 10 min after the acute injection of 0.8 mg/kg nicotine no change was found in the ratios of dopamine to its metabolites DOPAC and homovanillic acid in the substantia nigra, caudate-putamen, ...
The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology (Berl) 179: 255–261. Pecknold JC, McClure DJ, Appeltauer L, Wrzesinski L, Allan T (1982). Treatment of anxiety using fenobam (a nonbenzodiaze- pine) in ...
Nicotine Restores Wt-Like Levels of Reelin and GAD67 Gene Expression in Brain of Heterozygous Reeler Mice. Neurotox Res 24, 205–215 (2013). 47. Weeber, E. J. et al. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem 277, 39944–39952...
An insertion/deletion polymorphism in theSERTlinked promoter region (SERTLPR), previously reported to regulate mRNA expressionin vitro, has been associated with mental disorders and response to psychotropic drugs. Contradictory evidence, however, has raised questions about the role ofSERTLPRin regulating ...
Electronic cigarettes (ECs) are battery-operated devices designed to vaporise an e-liquid (a solution mainly consisting of glycerol, propylene glycol, distilled water, and flavourings, which may or may not contain nicotine) by heating an element (most commonly, a metal coil) that generates an in...