High amount of activity (12.73 ± 1.9% ID/g) is recorded in blood and significant uptake of the radiotracer occurs in the intestine (13.56 ± 3.3% ID/g), lungs (8.42 ± 0.8% ID/g), liver (5.81 ± 0.5% ID/g) and heart (4.70 ± 0.4% ID/g). Further studies are needed to ...
The affinity of compounds Ia and Ib was determined by measuring rat PDE10A2-cAMP inhibition: Ia pIC50=9.32, selective over other PDEs>1000 fold Ib pIC50=9.16, selective over other PDEs>1000 fold, except for PDE8A1>200 fold. Applications ...
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