Cancers such as those of the breast, prostate, kidney, and thyroid have a high incidence of metastases, particularly in the bone, which results in bone resorption, pain, hypercalcemia, spinal compression, decreased mobility, and even fractures (1). In addition, osteoporosis (bone resorption), a...
Comparison of the effects of calcium α-glycerophosphate and Ca2+ on prostaglandin synthesis in rabbit kidney medulla slices The effects of Fe 2+ and Cu 2+ on the generation of medullary prostaglandins E 2 and F 2α have been compared. Fe 2+ markedly promoted the lipid peroxidation of rabbit...
Doughnut Kidney doughnut pessary doughnut sign Doughnut Structure Douglas Douglas abscess Douglas bag Douglas cul-de-sac Douglas fold Douglas line Douglas Marjory Stoneman Douglas mechanism Douglas method Douglas pouch Douglas virus Douglas, Beverly Douglas, Claude G. Douglas, James Douglas, John C. ▼...
Modification of the Structure of a Metallopeptide: Synthesis and Biological Evaluation of 111In-Labeled DOTA-Conjugated Rhenium-Cyclized α-MSH Analogues Modification of the structure of a metallopeptide: synthesis and biological evaluation of 111In-labeled DOTA-conjugated rhenium- cyclized alpha-MSH...
The equilibrium inhibition constants (Ki) value of 1 at CXCR3 receptor was measured through competition binding assay using NBI74330 (Tocris Bioscience, Bristol, UK), an antagonist of CXCR3 receptor, [125I]CXCL10 (ViTrax Inc., Placentia, CA) and CXCR3 transfected human embryonic kidney (HEK...
uptake ratio, an 111In-labeled analog of gastrin (111In-1,4,7,10-tetraazacyclododecane-N,N',N",N'"-tetraacetic acid (DOTA)-His-His-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (H2-Met or APH070)) was shown to have a low kidney retention, but its uptake by the tumors was low (7)....
we modified the structure of [18F]Fmp2 with polyethylene glycol (PEG) chains. Herein, we report the synthesis of three novel18F-labeled pyridaben analogues, 4-chloro-2-tert-butyl-5-[2-[[1-[2-[18F]fluroethoxymethyl]-1H-1,2,3-triazol-4-yl]methyl]phenylmethoxy]-3(2H)-pyridazinone ([18...
In HERG channels, the general organization of the cytoplasmic domains remains obscure. Sequence conservation between HERG and HCN channels would be consistent with a localization of the carboxy terminal C-linker/CNBD as a compact tetrameric structure in a central position immediately below the cytoplas...
Increased awareness of the role played by the elements in human health and as etiologic factors in diseases (osteoporosis, heart disease, cancer, diabetes, kidney disease), as well as diagnostic and therapeutic adjuncts (obesity, inborn errors of metabolism, heart disease), has created an ...
Therefore, further studies are warranted to investigate the possible use of (99m)Tc-sCCK8 for scintigraphic imaging of CCK receptor-positive tumors in humans. 展开 关键词: Animals Humans Mice CHO Cells Peptides Radionuclide Imaging Receptors, Cholecystokinin Tissue Distribution Molecular Structure ...