Quantitative structure–activity relationship analysis to elucidate the clearance mechanisms of Tc-99m labeled quinolone antibiotics3D-QSARTc-99mLabeled quinolone antibioticsLiver uptakesKidney uptakesThis study
111In-girentuximab immunoSPECT is a helpful, noninvasive tool to further characterize incidentalomas of the kidney. Where there is targeting of the tumor, surgical intervention is warranted. In addition, it can be used to clarify the nature of lesions suspect for metastases in patients with a ...
Biodistribution result showed that the complex was selectively enriched in the tumor and cleared faster in non-target tissues, but unfortunately, its uptake in liver and kidney was relatively high, which may affect tumor imaging. In conclusion, radionuclide-labeled boron delivery agents are still in...
and glycogenolysis, while V3 binding induces adrenocorticotropic hormone (ACTH) secretion. Compared to vasopressin, terlipressin has a minimal effect on V2 receptors, which are responsible for promotion of water reabsorption in the collecting ducts of the kidney via stimulation of cyclic AMP ...
A high-resolution co-crystal structure (2.35) of PSB-17230 with human CD73 elucidated its binding interactions. Radioligand binding was employed to characterize competitive CD73 inhibitors and to study expression levels of the enzyme in tissues and tumor cell lines of different species. Moreover, ...
Name the functional unit of the kidney and describe its parts. Label the diagram (kidney internal structure): Identify the structure from the given description: The swelled base of the hair. What Am I? Compose a description of any one structure of the urinary system without revealing its name...
et al. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Inves 123, 5298–5309 (2013). 6. O' Leary, P. C. et al. Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast ...
Anatomical positions of liver (li), kidney (ki), bone (bo), and heart (ht) used for SUV quantification are exemplarily shown for the control mouse. B Standard uptake values (SUV, decay-corrected) for control mouse and ketoconazole treated mouse as a function of time (up to 2 h, in...
To date, the only way to evaluate the drug effect on living spheroids is to observe the growth of the whole structure of the cell aggregates4,8 and the staining of live/dead cells7. Immunostaining of fixed spheroids is therefore a useful way to evaluate drug effects in the core region of...
Chronic kidney disease (CKD) is one of the leading public health problems worldwide and finally progresses to end-stage renal disease. The therapeutic options of CKD are very limited. Thus, development of drug delivery systems specific-targeting to kidney may offer more options. Here we developed...