The difficulty in using established human melanoma cell lines as preclinical tumor models lies in their much lower MC1R density. The reported MC1R density in human M21 melanoma cells is only 1,281 copies per cell22, which is approximately 16 times less than that in B16-F10 mouse melanoma ce...
Other factors that may result in sustained venous hypertension are those that impede the pumping function of the leg muscles, such as conditions that reduce spontaneous movements (Parkinson's disease, stroke, spinal cord injuries or excessive sedation). This type of chronic venous insufficiency is ...