The guinea pig has been of immense value for decades as a model for human ailments such as infection, inflammation, toxicity, cardiovascular, gastrointestinal, deafness as well as for testing drug mechanisms and effects. In the human population, sex differences are known to exist in at least ...
Feasibility of 68Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syn... Lubberink et al., "Feasibility of (68) Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in ...
The mechanisms of protective immunity are closely related as well (11, 14, 33, 44). We have therefore chosen to evaluate the utility of CDV infection of ferrets as a model of MV infection, particula...COFFIN, D L. & LIU, C. (1957)- Studies on canine distemper infection by means of...
To analyze the structure and expression of NF1-GRD and produce a model mouse for this disease by gene targeting, we analyzed mouse NF1-GRD. We cloned four types of mouse NF1-GRD cDNA which were generated by alternative splicing. The expression pattern of typel-type4 NF1-GRD mRNA is ...
Concentrations of the cell suspension were approximately 1 × 107 cells/200 μL. Animal model To induce LNCaP tumor growth, male CB-17 SCID mice (6–8 weeks, Charles River Laboratories, Sulzfeld, Germany) were inoculated subcutaneously onto the right shoulder with LNCaP cells (approximately ...
Molecular imaging plays an important role in the non-invasive diagnosis and the guiding or monitoring of disease treatment. Different imaging modalities have been developed, and each method possesses unique strengths. While a variety of molecules have been used previously in nuclear imaging, the excep...
To achieve this, MFA combines a stoichiometric model, as the mathematical representation of the metabolic network, and measurement data from isotope labeling experiments [1, 2]. Taken together the model and the metabolite labeling information facilitate the calculation of in vivo fluxes not accessible...
More type of tumors with high FAP expressed should be used for validation of 99mTc-HYNIC-FAPI-04 SPECT imaging, such as the tumor model co-cultured with tumor matrix. Further studies dedicated to evaluating the diagnostic performance in tumor fibrosis are highly warranted....
[68Ga]Ga-NeoBOMB1, [68Ga]Ga-TacsBOMB5 might be more selective for the human GRPR expressed in PC-3 tumors compared to the mouse GRPR expressed in the mouse pancreas. Further clinical studies of [68Ga]Ga-TacsBOMB5 are needed to validate if the observations from the mouse model can be...
To achieve this, MFA combines a stoichiometric model, as the mathematical representation of the metabolic network, and measurement data from isotope labeling experiments [1, 2]. Taken together the model and the metabolite labeling information facilitate the calculation of in vivo fluxes not accessible...