Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as highly metastatic precursors and virtually unexplored. Technologies are primarily designed to detect single CTCs and often fail to account for the fragility of clus
(ii) the compact (or primitive) type, and (iii) the classic cored type [76]. It is proposed that these different morphologies represent the progressive stages of Aβ fibrillation [7,34,62,75]. Plaque formation is proposed to start as diffuse amorphous structures that mainly consist of aggre...
Over 90% of oral cancers are squamous cell carcinomas (SCCs), which arise from surface epithelial cells of the oral cavity [4]. Overall survival rates are strongly related to tumour stage at diagnosis [5]. The rates range from 80% for early stage cancers (I/II) to 30–50% in advanced...