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This review summarizes the pharmacology of these ligands and the apelin receptor, highlights the emerging physiologic and pathophysiological roles in a number of diseases, and recommends that Elabela/Toddler is a second endogenous peptide ligand of the apelin receptor protein....
(3D) structure in a whole brain. However, this type of techniques needs lengthy special preparation of the tissue specimen, which hinders broad application in life sciences. For example, diffusion staining of a whole brain3is extremely slow due to the scant extracellular space in the central ...
Indeed, as with CRT, there is evidence that systemic CNS-directed and IT chemotherapy may lead to brain abnormalities, such as decreased cerebral perfusion, slower resting electroencephalogram frequencies, white matter changes and enlargement of the ventricles and cortical sulci [7]. From the studies...
It surrounds the exterior of the central nervous system, filling also the four large ventricular cavities inside the brain, the spinal canal, and subarachnoid spaces. CSF is produced mainly in the choroid plexus, a structure present in the four ventricles, consisting of a single layer of ...
Another option to overcome this obstacle might be to bypass the blood–brain barrier by administering the antibiotics intrathecally. The term intrathecal (IT) is a general term including both intraventricular (IVT) and intralumbar (IL) injection in, respectively, the cerebral ventricles and the ...