Flavopiridol (Alvocidib, L86-8275, HMR-1275),又称夫拉平度,是ATP竞争性的CDK广谱抑制剂,作用于CDK1/2/4/6的选择性比作用于CDK7高,可抑制细胞增殖,具有抗癌活性。Flavopiridol也可抑制EGFR和PKA。 产品性质 英文别名(English Synonym) Flavopiridol, Alvocidib, L86-8275, HMR-1275 ...
英文名称 Flavopiridol (L86-8275) HCl 生化机理 Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 ...
英文名字 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone; HMR 1275; L86-8275; NSC 649890 供应商 BioVision 产品货号 2090-5 产品报价 ￥5440/5mg 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系...
L86-8275 [(-)cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1-methyl)- piperidinyl]-4H-1-benzopyran-4-one] is a flavone of novel structure. The purpose of this study was to determine in vitro whether L86-8275 is a more potent inhibitor of growth in breast carcinoma and lung...
【药物名称】Alvocidib hydrochloride, Flavopiridol, HL-275, MDL-107826A, HMR-1275, NSC-649890, L86-8275 化学结构式(Chemical Structure): 参考文献No. 12365 标题: Use of 4H-1-benzopyran-4-one derivs., 4H-1-benzopyran-4-one derivs. and medicines containing same 作者: Naik, R.G.; Lal, B....