A total of 4356 proteins were identified, with 17 proteins significantly increased in Cdkl5−/y nerve terminals and 26 significantly decreased (Additional File Table 1). Importantly, no CDKL5 peptides were detected in any sample from Cdkl5−/y rats, confirming our Western blot analysis (Fig...
The collected data were sex, age, ASA grade, BMI, operation time, intraoperative visual analogue score (VAS) for pain, need for additional analgesia, intraoperative changes in blood pressure and heart rate, blood loss, adverse events during surgery (dural sac tear, nerve root injury, vascular ...
c The vertebra was removed, leaving the nerve roots and dural sac intact. d A gross view of the removed vertebra and lesion Full size image Fig. 4 Radiographs of the lumbosacral spine 1 week after surgery (a, b). At 18-month follow-up, CT images demonstrated that L4–S1 vertebrae ...
cerevisiae α-glucosidase, human nerve growth factor and the lysosomal enzyme α-galactosidase A (hGLA) [21–23]. Recently, PhTAC125 was found to be a potential chassis for the production of hu- man CDKL5 (hCDKL5). hCDKL5 is a cyclin-dependent-like protein kinase abundantly expressed in...
Keywords: electronegative LDL; lectin-like oxidized LDL receptor-1 (LOX-1); nerve growth factor (NGF); neuronal differentiation; apoptosis 1. Introduction Dementia is the most common neurodegenerative disorder afflicting the aged. Growing evidence suggests a strong and likely causal association of ...