Phase I/II study of the tumour-targeting human monoclonal antibody-cytokine fusion protein L19-TNF in patients with advanced solid tumours. J Cancer Res Clin Oncol 2013 Mar; 139(3): 447-455.Spitaleri, G., Berardi, R., Pierantoni, C., De Pas, T., Noberasco, C., Libbra, C., ...
L19-tumor necrosis factor alpha (L19mTNF-; L), a fusion protein consisting of mouse TNF and the human antibody fragment L19 directed to the extra domain-B (ED-B) of fibronectin, is able to selectively target tumor vasculature and to exert a long-lasting therapeutic activity in combination ...
肩周炎的症状 肩周炎病程相对较长,起初肩部呈阵发性疼痛,多为慢性发作,以后疼痛逐渐加剧或钝痛、或刀割样痛,呈持续性,疼痛可向颈项及上肢(特别是肘部)扩散。 肩痛昼轻夜重,对气候变化(寒冷尤甚)敏感...
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郭登云, 担任山西金朋建筑装饰工程有限公司 等股东, 担任山西金朋建筑装饰工程有限公司等高管。 任职全景图 投资、任职的关联公司 股权穿透图 挖掘深层股权结构 商业关系图 一图看清商业版图 合作伙伴 了解老板关系,合作伙伴 关联企业1 担任法定代表人0 担任股东1 担任高管1 所有任职企业1 作为最终受益人0 所属...
Antibody-based delivery of tumor necrosis factor (L19-TNF伪) and interleukin-2 (L19-IL2) to tumor-associated blood vessels has potent immunological and anticancer activity in the syngeneic J558L BALB/c myeloma model. J Cancer Res Clin Oncol. 2018;144(3):499-507....
Boselli, SNeri, DSpitalieri G, De Pas T, Noberasco C, et al.: Phase I/II study of the tumor-targeting human L19-TNFa monoclonal antibody-cy- tokine fusion protein in patients with advanced solid tumors. Ann Oncol 2010;21:VIII 164....
Papadia F, Basso V, Patuzzo R et al (2013) Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19–TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma. J Surg Oncol 107(2):173–179. : 10.1002/...
Dose-limiting toxicity occurred either at 17μg/kg L19TNF or at 75mg/m 2 doxorubicin. RD is 13μg/kg L19TNF plus 60mg/m 2 doxorubicin. In 15 STS patients of the extension cohort evaluable for efficacy, antitumour activity was observed with complete remission in 1, partial remission in ...
Efficacy of Neoadjuvant Intratumoral Darleukin/Fibromun (L19IL2+L19TNF) in Patients with Clinical Stage IIIB/C Melanoma (Neo-DREAM)Annals of Surgical Oncology -doi:10.1245/s10434-022-11447-xSaif, AreebaRossi, Alexander J.Sarnaik, AmodHernandez, Jonathan M....